Developmental disruptions and behavioral impairments in rats following in utero RNAi of Dyx1c1

Abstract Developmental malformations of cortex have been shown to co-occur with language, learning, and other cognitive deficits in humans. Rodent models have repeatedly shown that animals with such developmental malformations have deficits related to auditory processing and learning. More specifica...

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Veröffentlicht in:	Brain research bulletin 2007-03, Vol.71 (5), p.508-514
Hauptverfasser:	Threlkeld, Steven W, McClure, Melissa M, Bai, Jilin, Wang, Yu, LoTurco, Joe J, Rosen, Glenn D, Fitch, R. Holly
Format:	Artikel
Sprache:	eng
Schlagworte:	Acoustic Stimulation Analysis of Variance Animals Animals, Newborn Auditory Perceptual Disorders - etiology Auditory processing impairment Developmental dyslexia Disease Models, Animal Dyslexia - complications Dyslexia - genetics Dyslexia - pathology Female Humans In utero electroporation Learning Disorders - etiology Maze Learning - physiology Nerve Tissue Proteins - genetics Neurology Nuclear Proteins - genetics Rats Rats, Wistar RNA Interference - physiology RNAi Space Perception - physiology Spatial learning impairment Transfection Transfection - methods Uterus - physiology
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