Expression and activation of TGF-β isoforms in acute allergen-induced remodelling in asthma

Background: Airway wall remodelling and inflammation are features of chronic asthma. Transforming growth factor β (TGF-β) has been implicated in these processes. Aim: To determine the effect of allergen challenge on airway inflammation and remodelling and whether TGF-β isoforms and the Smad signalli...

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Veröffentlicht in:	Thorax 2007-04, Vol.62 (4), p.307-313
Hauptverfasser:	Torrego, Alfons, Hew, Mark, Oates, Tim, Sukkar, Maria, Fan Chung, Kian
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Allergens - adverse effects Asthma Asthma - metabolism Asthma - pathology Asthma - physiopathology Biological and medical sciences Biopsy - methods Bronchi - pathology Bronchitis - pathology Bronchoscopy - methods Chronic Disease Chronic obstructive pulmonary disease, asthma Eosinophils - pathology FEV1 Fiber Optic Technology Forced Expiratory Volume - physiology forced expiratory volume in 1 s Humans major basic protein MBP Medical sciences neutrophil elastase Neutrophils - pathology Pneumology Respiratory Mucosa - pathology SBM sub-basement membrane TGF-β Transforming Growth Factor beta - metabolism transforming growth factor-β
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