Inverse Relationship between Microsatellite Instability and K- ras and p53 Gene Alterations in Colon Cancer

Some studies have shown an inverse relationship between microsatellite instability in colon cancer and mutations in p53 and K- ras, whereas others have not. We therefore evaluated these features in a population-based sample of 496 individuals with colon cancer. Microsatellite instability was determi...

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Veröffentlicht in:	The American journal of pathology 2001-04, Vol.158 (4), p.1517-1524
Hauptverfasser:	Samowitz, Wade S., Holden, Joseph A., Curtin, Karen, Edwards, Sandra L., Walker, Adrianne R., Lin, Heather A., Robertson, Margaret A., Nichols, Melanie F., Gruenthal, Kristin M., Lynch, Beverly J., Leppert, Mark F., Slattery, Martha L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Biological and medical sciences Codon - genetics Colonic Neoplasms - genetics Colonic Neoplasms - metabolism Gastroenterology. Liver. Pancreas. Abdomen Genes, p53 - genetics Genes, ras - genetics Humans Medical sciences Microsatellite Repeats - genetics Middle Aged Mutation Regular Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Tumor Suppressor Protein p53 - metabolism Tumors
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