Pyeloureteric peristalsis: role of atypical smooth muscle cells and interstitial cells of Cajal-like cells as pacemakers
Pyeloureteric peristalsis has long been considered to be triggered by pacemaker atypical smooth muscle cells (SMC) located in the proximal regions of the renal pelvis. However, interstitial cells with many of the morphological features and c- Kit immuno-reactivity of interstitial cells of Cajal (ICC...
Gespeichert in:
| Veröffentlicht in: | The Journal of physiology 2006-11, Vol.576 (3), p.695-705 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 705 |
|---|---|
| container_issue | 3 |
| container_start_page | 695 |
| container_title | The Journal of physiology |
| container_volume | 576 |
| creator | Lang, Richard J. Tonta, Mary A. Zoltkowski, Beata Z. Meeker, William F. Wendt, Igor Parkington, Helena C. |
| description | Pyeloureteric peristalsis has long been considered to be triggered by pacemaker atypical smooth muscle cells (SMC) located
in the proximal regions of the renal pelvis. However, interstitial cells with many of the morphological features and c- Kit immuno-reactivity of interstitial cells of Cajal (ICC), the established pacemaker cells in the intestine, have been demonstrated
to be present in small numbers within the ureteropelvic junction (UPJ) of many mammals. Freshly isolated ICC-like cells (ICC-LC)
of the mouse UPJ also display autorhyhmicity. This review discusses the notion that ureteric peristalsis depends on the presence
of both atypical SMC and ICC-LC which form separate but interconnected networks that drive electrically quiescent typical
SMC. In contrast to the intestine or prostate, all regenerative potential discharge in the mouse UPJ is abolished by the L-type
Ca 2+ channel blocker nifedipine revealing a fundamental pacemaker signal. Whether these pacemaker transients arise from atypical
SMC or ICC-LC or both has yet to be established. We speculate that the presence of spontaneously active ICC-LC in the distal
regions of the UPJ maintains rudimentary peristaltic waves and movement of urine towards the bladder after pyeloureteral obstruction
or pyeloplasty and disconnection from the proximal pacemaker drive. |
| doi_str_mv | 10.1113/jphysiol.2006.116855 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1890417</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>69024607</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5548-71e80e5433b6a90ec8a191f3c55bcd5d6c3a18219f86ec9ffd145c80b6f1e6063</originalsourceid><addsrcrecordid>eNqNkU9v1DAQxS0EokvhGyCUE5xSPHHs2ByQ0Iq_qkQP5Wx5nUnjrbMOdkLJt8erLAVuXGxp5vfezOgR8hzoBQCw1_uxX5IL_qKiVOSSkJw_IBuohSqbRrGHZENpVZWs4XBGnqS0pxQYVeoxOQOhaq6E2pCfVwv6MEecMDpbjPlNk_HJpTdFDB6L0BVmWkZnjS_SEMLUF8OcbO5Y9D4V5tAW7pDVaXKTy9BazrKt2Rtfend7j6ZiNBYHc5vpp-RRl-fgs9N_Tr59eH-9_VRefv34efvusrSc17JsACVFXjO2E0ZRtNKAgo7l7s62vBWWGZAVqE4KtKrrWqi5lXQnOkBBBTsnb1ffcd4N2Fo8TNF4PUY3mLjoYJz-t3Nwvb4JPzRIRWtossHLk0EM32dMkx5cOh5kDhjmpIWiVS3oEaxX0MaQUsTufghQfYxM_45MHyPTa2RZ9uLvBf-IThllQK3AnfO4_Jepvv5yBZLKrH21ant309-5iHqlU7AOp0XzRmiWT-DsF6NPuO4</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>69024607</pqid></control><display><type>article</type><title>Pyeloureteric peristalsis: role of atypical smooth muscle cells and interstitial cells of Cajal-like cells as pacemakers</title><source>MEDLINE</source><source>Wiley Free Archive</source><source>EZB Free E-Journals</source><source>IngentaConnect Backfiles</source><source>PubMed Central</source><source>Wiley Blackwell Journals</source><creator>Lang, Richard J. ; Tonta, Mary A. ; Zoltkowski, Beata Z. ; Meeker, William F. ; Wendt, Igor ; Parkington, Helena C.</creator><creatorcontrib>Lang, Richard J. ; Tonta, Mary A. ; Zoltkowski, Beata Z. ; Meeker, William F. ; Wendt, Igor ; Parkington, Helena C.</creatorcontrib><description>Pyeloureteric peristalsis has long been considered to be triggered by pacemaker atypical smooth muscle cells (SMC) located
in the proximal regions of the renal pelvis. However, interstitial cells with many of the morphological features and c- Kit immuno-reactivity of interstitial cells of Cajal (ICC), the established pacemaker cells in the intestine, have been demonstrated
to be present in small numbers within the ureteropelvic junction (UPJ) of many mammals. Freshly isolated ICC-like cells (ICC-LC)
of the mouse UPJ also display autorhyhmicity. This review discusses the notion that ureteric peristalsis depends on the presence
of both atypical SMC and ICC-LC which form separate but interconnected networks that drive electrically quiescent typical
SMC. In contrast to the intestine or prostate, all regenerative potential discharge in the mouse UPJ is abolished by the L-type
Ca 2+ channel blocker nifedipine revealing a fundamental pacemaker signal. Whether these pacemaker transients arise from atypical
SMC or ICC-LC or both has yet to be established. We speculate that the presence of spontaneously active ICC-LC in the distal
regions of the UPJ maintains rudimentary peristaltic waves and movement of urine towards the bladder after pyeloureteral obstruction
or pyeloplasty and disconnection from the proximal pacemaker drive.</description><identifier>ISSN: 0022-3751</identifier><identifier>EISSN: 1469-7793</identifier><identifier>DOI: 10.1113/jphysiol.2006.116855</identifier><identifier>PMID: 16945969</identifier><language>eng</language><publisher>Oxford, UK: The Physiological Society</publisher><subject>Action Potentials - drug effects ; Action Potentials - physiology ; Animals ; Biological Clocks - physiology ; Calcium - physiology ; Kidney Pelvis - physiology ; Mice ; Muscle Contraction - physiology ; Muscle, Smooth - cytology ; Muscle, Smooth - innervation ; Muscle, Smooth - physiology ; Patch-Clamp Techniques ; Peristalsis - physiology ; Stem Cell Factor ; Symposium Reports ; Ureter - physiology</subject><ispartof>The Journal of physiology, 2006-11, Vol.576 (3), p.695-705</ispartof><rights>2006 The Journal of Physiology © 2006 The Physiological Society</rights><rights>2006 The Authors. Journal compilation © 2006 The Physiological Society 2006</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5548-71e80e5433b6a90ec8a191f3c55bcd5d6c3a18219f86ec9ffd145c80b6f1e6063</citedby><cites>FETCH-LOGICAL-c5548-71e80e5433b6a90ec8a191f3c55bcd5d6c3a18219f86ec9ffd145c80b6f1e6063</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1890417/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1890417/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,1417,1433,27924,27925,45574,45575,46409,46833,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16945969$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lang, Richard J.</creatorcontrib><creatorcontrib>Tonta, Mary A.</creatorcontrib><creatorcontrib>Zoltkowski, Beata Z.</creatorcontrib><creatorcontrib>Meeker, William F.</creatorcontrib><creatorcontrib>Wendt, Igor</creatorcontrib><creatorcontrib>Parkington, Helena C.</creatorcontrib><title>Pyeloureteric peristalsis: role of atypical smooth muscle cells and interstitial cells of Cajal-like cells as pacemakers</title><title>The Journal of physiology</title><addtitle>J Physiol</addtitle><description>Pyeloureteric peristalsis has long been considered to be triggered by pacemaker atypical smooth muscle cells (SMC) located
in the proximal regions of the renal pelvis. However, interstitial cells with many of the morphological features and c- Kit immuno-reactivity of interstitial cells of Cajal (ICC), the established pacemaker cells in the intestine, have been demonstrated
to be present in small numbers within the ureteropelvic junction (UPJ) of many mammals. Freshly isolated ICC-like cells (ICC-LC)
of the mouse UPJ also display autorhyhmicity. This review discusses the notion that ureteric peristalsis depends on the presence
of both atypical SMC and ICC-LC which form separate but interconnected networks that drive electrically quiescent typical
SMC. In contrast to the intestine or prostate, all regenerative potential discharge in the mouse UPJ is abolished by the L-type
Ca 2+ channel blocker nifedipine revealing a fundamental pacemaker signal. Whether these pacemaker transients arise from atypical
SMC or ICC-LC or both has yet to be established. We speculate that the presence of spontaneously active ICC-LC in the distal
regions of the UPJ maintains rudimentary peristaltic waves and movement of urine towards the bladder after pyeloureteral obstruction
or pyeloplasty and disconnection from the proximal pacemaker drive.</description><subject>Action Potentials - drug effects</subject><subject>Action Potentials - physiology</subject><subject>Animals</subject><subject>Biological Clocks - physiology</subject><subject>Calcium - physiology</subject><subject>Kidney Pelvis - physiology</subject><subject>Mice</subject><subject>Muscle Contraction - physiology</subject><subject>Muscle, Smooth - cytology</subject><subject>Muscle, Smooth - innervation</subject><subject>Muscle, Smooth - physiology</subject><subject>Patch-Clamp Techniques</subject><subject>Peristalsis - physiology</subject><subject>Stem Cell Factor</subject><subject>Symposium Reports</subject><subject>Ureter - physiology</subject><issn>0022-3751</issn><issn>1469-7793</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU9v1DAQxS0EokvhGyCUE5xSPHHs2ByQ0Iq_qkQP5Wx5nUnjrbMOdkLJt8erLAVuXGxp5vfezOgR8hzoBQCw1_uxX5IL_qKiVOSSkJw_IBuohSqbRrGHZENpVZWs4XBGnqS0pxQYVeoxOQOhaq6E2pCfVwv6MEecMDpbjPlNk_HJpTdFDB6L0BVmWkZnjS_SEMLUF8OcbO5Y9D4V5tAW7pDVaXKTy9BazrKt2Rtfend7j6ZiNBYHc5vpp-RRl-fgs9N_Tr59eH-9_VRefv34efvusrSc17JsACVFXjO2E0ZRtNKAgo7l7s62vBWWGZAVqE4KtKrrWqi5lXQnOkBBBTsnb1ffcd4N2Fo8TNF4PUY3mLjoYJz-t3Nwvb4JPzRIRWtossHLk0EM32dMkx5cOh5kDhjmpIWiVS3oEaxX0MaQUsTufghQfYxM_45MHyPTa2RZ9uLvBf-IThllQK3AnfO4_Jepvv5yBZLKrH21ant309-5iHqlU7AOp0XzRmiWT-DsF6NPuO4</recordid><startdate>200611</startdate><enddate>200611</enddate><creator>Lang, Richard J.</creator><creator>Tonta, Mary A.</creator><creator>Zoltkowski, Beata Z.</creator><creator>Meeker, William F.</creator><creator>Wendt, Igor</creator><creator>Parkington, Helena C.</creator><general>The Physiological Society</general><general>Blackwell Publishing Ltd</general><general>Blackwell Science Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>200611</creationdate><title>Pyeloureteric peristalsis: role of atypical smooth muscle cells and interstitial cells of Cajal-like cells as pacemakers</title><author>Lang, Richard J. ; Tonta, Mary A. ; Zoltkowski, Beata Z. ; Meeker, William F. ; Wendt, Igor ; Parkington, Helena C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5548-71e80e5433b6a90ec8a191f3c55bcd5d6c3a18219f86ec9ffd145c80b6f1e6063</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Action Potentials - drug effects</topic><topic>Action Potentials - physiology</topic><topic>Animals</topic><topic>Biological Clocks - physiology</topic><topic>Calcium - physiology</topic><topic>Kidney Pelvis - physiology</topic><topic>Mice</topic><topic>Muscle Contraction - physiology</topic><topic>Muscle, Smooth - cytology</topic><topic>Muscle, Smooth - innervation</topic><topic>Muscle, Smooth - physiology</topic><topic>Patch-Clamp Techniques</topic><topic>Peristalsis - physiology</topic><topic>Stem Cell Factor</topic><topic>Symposium Reports</topic><topic>Ureter - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lang, Richard J.</creatorcontrib><creatorcontrib>Tonta, Mary A.</creatorcontrib><creatorcontrib>Zoltkowski, Beata Z.</creatorcontrib><creatorcontrib>Meeker, William F.</creatorcontrib><creatorcontrib>Wendt, Igor</creatorcontrib><creatorcontrib>Parkington, Helena C.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The Journal of physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lang, Richard J.</au><au>Tonta, Mary A.</au><au>Zoltkowski, Beata Z.</au><au>Meeker, William F.</au><au>Wendt, Igor</au><au>Parkington, Helena C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pyeloureteric peristalsis: role of atypical smooth muscle cells and interstitial cells of Cajal-like cells as pacemakers</atitle><jtitle>The Journal of physiology</jtitle><addtitle>J Physiol</addtitle><date>2006-11</date><risdate>2006</risdate><volume>576</volume><issue>3</issue><spage>695</spage><epage>705</epage><pages>695-705</pages><issn>0022-3751</issn><eissn>1469-7793</eissn><abstract>Pyeloureteric peristalsis has long been considered to be triggered by pacemaker atypical smooth muscle cells (SMC) located
in the proximal regions of the renal pelvis. However, interstitial cells with many of the morphological features and c- Kit immuno-reactivity of interstitial cells of Cajal (ICC), the established pacemaker cells in the intestine, have been demonstrated
to be present in small numbers within the ureteropelvic junction (UPJ) of many mammals. Freshly isolated ICC-like cells (ICC-LC)
of the mouse UPJ also display autorhyhmicity. This review discusses the notion that ureteric peristalsis depends on the presence
of both atypical SMC and ICC-LC which form separate but interconnected networks that drive electrically quiescent typical
SMC. In contrast to the intestine or prostate, all regenerative potential discharge in the mouse UPJ is abolished by the L-type
Ca 2+ channel blocker nifedipine revealing a fundamental pacemaker signal. Whether these pacemaker transients arise from atypical
SMC or ICC-LC or both has yet to be established. We speculate that the presence of spontaneously active ICC-LC in the distal
regions of the UPJ maintains rudimentary peristaltic waves and movement of urine towards the bladder after pyeloureteral obstruction
or pyeloplasty and disconnection from the proximal pacemaker drive.</abstract><cop>Oxford, UK</cop><pub>The Physiological Society</pub><pmid>16945969</pmid><doi>10.1113/jphysiol.2006.116855</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-3751 |
| ispartof | The Journal of physiology, 2006-11, Vol.576 (3), p.695-705 |
| issn | 0022-3751 1469-7793 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1890417 |
| source | MEDLINE; Wiley Free Archive; EZB Free E-Journals; IngentaConnect Backfiles; PubMed Central; Wiley Blackwell Journals |
| subjects | Action Potentials - drug effects Action Potentials - physiology Animals Biological Clocks - physiology Calcium - physiology Kidney Pelvis - physiology Mice Muscle Contraction - physiology Muscle, Smooth - cytology Muscle, Smooth - innervation Muscle, Smooth - physiology Patch-Clamp Techniques Peristalsis - physiology Stem Cell Factor Symposium Reports Ureter - physiology |
| title | Pyeloureteric peristalsis: role of atypical smooth muscle cells and interstitial cells of Cajal-like cells as pacemakers |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-01T05%3A52%3A49IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Pyeloureteric%20peristalsis:%20role%20of%20atypical%20smooth%20muscle%20cells%20and%20interstitial%20cells%20of%20Cajal-like%20cells%20as%20pacemakers&rft.jtitle=The%20Journal%20of%20physiology&rft.au=Lang,%20Richard%20J.&rft.date=2006-11&rft.volume=576&rft.issue=3&rft.spage=695&rft.epage=705&rft.pages=695-705&rft.issn=0022-3751&rft.eissn=1469-7793&rft_id=info:doi/10.1113/jphysiol.2006.116855&rft_dat=%3Cproquest_pubme%3E69024607%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=69024607&rft_id=info:pmid/16945969&rfr_iscdi=true |