Damage control mechanisms in articular cartilage: the role of the insulin-like growth factor I axis

Articular chondrocytes maintain cartilage throughout life by replacing lost or damaged matrix with freshly synthesized material. Synthesis activity is regulated, rapidly increasing to well above basal levels in response to cartilage injury. Such responses suggest that synthesis activity is linked to...

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Veröffentlicht in:	The Iowa orthopaedic journal 2000, Vol.20, p.1-10
Hauptverfasser:	Martin, J A, Scherb, M B, Lembke, L A, Buckwalter, J A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Age Factors Aged Aged, 80 and over Biological Availability Cartilage, Articular - growth & development Cartilage, Articular - injuries Chondrocytes - physiology Fibronectins - physiology Humans Immunohistochemistry Insulin-Like Growth Factor Binding Protein 1 - physiology Insulin-Like Growth Factor Binding Protein 3 - analysis Insulin-Like Growth Factor Binding Protein 3 - physiology Insulin-Like Growth Factor I - physiology Middle Aged Osteoarthritis - etiology Osteoarthritis - metabolism Tissue Distribution
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