Dectin-1 is required for β-glucan recognition and control of fungal infection

β-Glucan is one of the most abundant polysaccharides in fungal pathogens, yet its importance in antifungal immunity is unclear. Here we show that deficiency of dectin-1, the myeloid receptor for β-glucan, rendered mice susceptible to infection with Candida albicans . Dectin-1-deficient leukocytes de...

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Veröffentlicht in:	Nature immunology 2007-01, Vol.8 (1), p.31-38
Hauptverfasser:	Taylor, Philip R, Tsoni, S Vicky, Willment, Janet A, Dennehy, Kevin M, Rosas, Marcela, Findon, Helen, Haynes, Ken, Steele, Chad, Botto, Marina, Gordon, Siamon, Brown, Gordon D
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals beta-Glucans - immunology beta-Glucans - metabolism Biomedical and Life Sciences Biomedicine Candida - immunology Candidiasis Candidiasis - immunology Candidiasis - prevention & control Control Female Genetic Predisposition to Disease Health aspects Immune response Immunology Infectious Diseases Lectins, C-Type Leukocytes - immunology Membrane Proteins - genetics Membrane Proteins - metabolism Membrane Proteins - physiology Mice Mice, Knockout Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Nerve Tissue Proteins - physiology Regulation
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