Oleic acid-induced cholelithiasis in rabbits. Changes in bile composition and gallbladder morphology
Feeding oleic acid to rabbits resulted in a progressive rise in bile concentration of allodeoxycholic acid, expansion of the bile salt pool, and depression of de novo hepatic bile acid synthesis. There was also an increase in cholesterol saturation in bile. The gallstones that formed contained trace...
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| Veröffentlicht in: | The American journal of pathology 1986-07, Vol.124 (1), p.18-24 |
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| creator | Lee, SP Tasman-Jones, C Carlisle, V |
| description | Feeding oleic acid to rabbits resulted in a progressive rise in bile concentration of allodeoxycholic acid, expansion of the bile salt pool, and depression of de novo hepatic bile acid synthesis. There was also an increase in cholesterol saturation in bile. The gallstones that formed contained traces of cholesterol but were composed mainly of salts of allodeoxycholic acid. The data suggest that oleic acid feeding results in increased rate of cholestanol and allodeoxycholic acid metabolism. Morphologically, these biochemical events were accompanied by early reactive changes in the gallbladder epithelium characterized by marked increase in cell proliferation and mucus hypersecretion. In addition, there was the early formation of interepithelial cell vacuoles and, later, Rokitansky-Aschoff sinuses. These cellular reactions reflect the dramatic and important changes that take place in the gallbladder before gallstone formation. |
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Changes in bile composition and gallbladder morphology</title><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><creator>Lee, SP ; Tasman-Jones, C ; Carlisle, V</creator><creatorcontrib>Lee, SP ; Tasman-Jones, C ; Carlisle, V</creatorcontrib><description>Feeding oleic acid to rabbits resulted in a progressive rise in bile concentration of allodeoxycholic acid, expansion of the bile salt pool, and depression of de novo hepatic bile acid synthesis. There was also an increase in cholesterol saturation in bile. The gallstones that formed contained traces of cholesterol but were composed mainly of salts of allodeoxycholic acid. The data suggest that oleic acid feeding results in increased rate of cholestanol and allodeoxycholic acid metabolism. Morphologically, these biochemical events were accompanied by early reactive changes in the gallbladder epithelium characterized by marked increase in cell proliferation and mucus hypersecretion. In addition, there was the early formation of interepithelial cell vacuoles and, later, Rokitansky-Aschoff sinuses. These cellular reactions reflect the dramatic and important changes that take place in the gallbladder before gallstone formation.</description><identifier>ISSN: 0002-9440</identifier><identifier>EISSN: 1525-2191</identifier><identifier>PMID: 3728645</identifier><identifier>CODEN: AJPAA4</identifier><language>eng</language><publisher>Bethesda, MD: ASIP</publisher><subject>Administration, Oral ; Animals ; Bile Acids and Salts - analysis ; Bile Acids and Salts - biosynthesis ; Biological and medical sciences ; Cholelithiasis - chemically induced ; Cholelithiasis - pathology ; Cholesterol - analysis ; Female ; Gallbladder - drug effects ; Gallbladder - metabolism ; Gallbladder - pathology ; Gastroenterology. Liver. Pancreas. Abdomen ; Liver. Biliary tract. Portal circulation. Exocrine pancreas ; Male ; Medical sciences ; Oleic Acid ; Oleic Acids - pharmacology ; Other diseases. Semiology ; Rabbits</subject><ispartof>The American journal of pathology, 1986-07, Vol.124 (1), p.18-24</ispartof><rights>1986 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1888183/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1888183/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,53791,53793</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8745073$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3728645$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lee, SP</creatorcontrib><creatorcontrib>Tasman-Jones, C</creatorcontrib><creatorcontrib>Carlisle, V</creatorcontrib><title>Oleic acid-induced cholelithiasis in rabbits. Changes in bile composition and gallbladder morphology</title><title>The American journal of pathology</title><addtitle>Am J Pathol</addtitle><description>Feeding oleic acid to rabbits resulted in a progressive rise in bile concentration of allodeoxycholic acid, expansion of the bile salt pool, and depression of de novo hepatic bile acid synthesis. There was also an increase in cholesterol saturation in bile. The gallstones that formed contained traces of cholesterol but were composed mainly of salts of allodeoxycholic acid. The data suggest that oleic acid feeding results in increased rate of cholestanol and allodeoxycholic acid metabolism. Morphologically, these biochemical events were accompanied by early reactive changes in the gallbladder epithelium characterized by marked increase in cell proliferation and mucus hypersecretion. In addition, there was the early formation of interepithelial cell vacuoles and, later, Rokitansky-Aschoff sinuses. These cellular reactions reflect the dramatic and important changes that take place in the gallbladder before gallstone formation.</description><subject>Administration, Oral</subject><subject>Animals</subject><subject>Bile Acids and Salts - analysis</subject><subject>Bile Acids and Salts - biosynthesis</subject><subject>Biological and medical sciences</subject><subject>Cholelithiasis - chemically induced</subject><subject>Cholelithiasis - pathology</subject><subject>Cholesterol - analysis</subject><subject>Female</subject><subject>Gallbladder - drug effects</subject><subject>Gallbladder - metabolism</subject><subject>Gallbladder - pathology</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Liver. Biliary tract. Portal circulation. Exocrine pancreas</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Oleic Acid</subject><subject>Oleic Acids - pharmacology</subject><subject>Other diseases. Semiology</subject><subject>Rabbits</subject><issn>0002-9440</issn><issn>1525-2191</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkElLxEAQhRtRxnH0Jwh90GOkq7N1LoIMbiB40XOoXpLU0FlIZ5T590YdBj0VVe_V9-AdsSWkMo0kFHDMlkIIGRVJIk7ZWQibec1iJRZsEedSZUm6ZPbVOzIcDdmIOrs1znLT9N55mhrCQIFTx0fUmqZww9cNdrX7uWnyjpu-HfpAE_Udx87yGr3XHq11I2_7cZhJfb07ZycV-uAu9nPF3h_u39ZP0cvr4_P67iVqYimmSIEFKxILKleF0cJmWNgsVa5wVe6kyzFRVWpkDoUoUjBxloEEW1Rag0YL8Yrd_nKHrW6dNa6bRvTlMFKL467skcr_SkdNWfcfJSilQMUz4PIv4PC5r2vWr_Y6BoO-GrEzFA42lSepyL8x17-2hurmk0ZXhnYuZoZCiZsBZFLCnBl_AaRYg84</recordid><startdate>19860701</startdate><enddate>19860701</enddate><creator>Lee, SP</creator><creator>Tasman-Jones, C</creator><creator>Carlisle, V</creator><general>ASIP</general><general>American Society for Investigative Pathology</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>5PM</scope></search><sort><creationdate>19860701</creationdate><title>Oleic acid-induced cholelithiasis in rabbits. Changes in bile composition and gallbladder morphology</title><author>Lee, SP ; Tasman-Jones, C ; Carlisle, V</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h320t-81d1d04d18789cb0d6a9d658e9ef7e2e7a48f5c27190951c366121d9fbb1bad13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>Administration, Oral</topic><topic>Animals</topic><topic>Bile Acids and Salts - analysis</topic><topic>Bile Acids and Salts - biosynthesis</topic><topic>Biological and medical sciences</topic><topic>Cholelithiasis - chemically induced</topic><topic>Cholelithiasis - pathology</topic><topic>Cholesterol - analysis</topic><topic>Female</topic><topic>Gallbladder - drug effects</topic><topic>Gallbladder - metabolism</topic><topic>Gallbladder - pathology</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Liver. Biliary tract. Portal circulation. Exocrine pancreas</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Oleic Acid</topic><topic>Oleic Acids - pharmacology</topic><topic>Other diseases. Semiology</topic><topic>Rabbits</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lee, SP</creatorcontrib><creatorcontrib>Tasman-Jones, C</creatorcontrib><creatorcontrib>Carlisle, V</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The American journal of pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lee, SP</au><au>Tasman-Jones, C</au><au>Carlisle, V</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Oleic acid-induced cholelithiasis in rabbits. Changes in bile composition and gallbladder morphology</atitle><jtitle>The American journal of pathology</jtitle><addtitle>Am J Pathol</addtitle><date>1986-07-01</date><risdate>1986</risdate><volume>124</volume><issue>1</issue><spage>18</spage><epage>24</epage><pages>18-24</pages><issn>0002-9440</issn><eissn>1525-2191</eissn><coden>AJPAA4</coden><abstract>Feeding oleic acid to rabbits resulted in a progressive rise in bile concentration of allodeoxycholic acid, expansion of the bile salt pool, and depression of de novo hepatic bile acid synthesis. There was also an increase in cholesterol saturation in bile. The gallstones that formed contained traces of cholesterol but were composed mainly of salts of allodeoxycholic acid. The data suggest that oleic acid feeding results in increased rate of cholestanol and allodeoxycholic acid metabolism. Morphologically, these biochemical events were accompanied by early reactive changes in the gallbladder epithelium characterized by marked increase in cell proliferation and mucus hypersecretion. In addition, there was the early formation of interepithelial cell vacuoles and, later, Rokitansky-Aschoff sinuses. These cellular reactions reflect the dramatic and important changes that take place in the gallbladder before gallstone formation.</abstract><cop>Bethesda, MD</cop><pub>ASIP</pub><pmid>3728645</pmid><tpages>7</tpages></addata></record> |
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| ispartof | The American journal of pathology, 1986-07, Vol.124 (1), p.18-24 |
| issn | 0002-9440 1525-2191 |
| language | eng |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Administration, Oral Animals Bile Acids and Salts - analysis Bile Acids and Salts - biosynthesis Biological and medical sciences Cholelithiasis - chemically induced Cholelithiasis - pathology Cholesterol - analysis Female Gallbladder - drug effects Gallbladder - metabolism Gallbladder - pathology Gastroenterology. Liver. Pancreas. Abdomen Liver. Biliary tract. Portal circulation. Exocrine pancreas Male Medical sciences Oleic Acid Oleic Acids - pharmacology Other diseases. Semiology Rabbits |
| title | Oleic acid-induced cholelithiasis in rabbits. Changes in bile composition and gallbladder morphology |
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