Macrophages and multicellular tumor spheroids in co-culture: a three- dimensional model to study tumor-host interactions. Evidence for macrophage-mediated tumor cell proliferation and migration

In a new co-culture model involving multicellular tumor spheroids and different phenotypes of human macrophages, we studied the effects of the latter on migration and proliferation of the human colon carcinoma cell line, HRT-18. The macrophage phenotypes are detectable with monoclonal antibodies and...

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Veröffentlicht in:	The American journal of pathology 1993-11, Vol.143 (5), p.1406-1415
Hauptverfasser:	Hauptmann, S, Zwadlo-Klarwasser, G, Jansen, M, Klosterhalfen, B, Kirkpatrick, CJ
Format:	Artikel
Sprache:	eng
Schlagworte:	Carcinoma - pathology Cell Adhesion Cell Communication Cell Division Cell Movement Cells, Cultured Humans Macrophages - pathology Macrophages - ultrastructure Microscopy, Electron Microscopy, Electron, Scanning Models, Biological Rectal Neoplasms - pathology Tumor Cells, Cultured
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