Differential permeability of the blood-brain barrier in experimental brain metastases produced by human neoplasms implanted into nude mice
This study clarified whether and when the blood-brain barrier in experimental brain metastases is impaired by using hydrosoluble sodium fluorescein (MW 376) as a blood-brain barrier function indicator. Cells from eight human tumor lines (four melanomas, two breast carcinomas, one colon carcinoma, an...
Gespeichert in:
| Veröffentlicht in: | The American journal of pathology 1992-11, Vol.141 (5), p.1115-1124 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1124 |
|---|---|
| container_issue | 5 |
| container_start_page | 1115 |
| container_title | The American journal of pathology |
| container_volume | 141 |
| creator | Zhang, RD Price, JE Fujimaki, T Bucana, CD Fidler, IJ |
| description | This study clarified whether and when the blood-brain barrier in experimental brain metastases is impaired by using hydrosoluble sodium fluorescein (MW 376) as a blood-brain barrier function indicator. Cells from eight human tumor lines (four melanomas, two breast carcinomas, one colon carcinoma, and one renal carcinoma) were inoculated into the internal carotid artery of nude mice. Brain metastases at different stages of development were sampled and the permeability of the blood-brain barrier around the metastases determined. Histologic examination showed two patterns of tumor growth. In the first, tumor cells formed isolated, well-defined nodules in the parenchyma of the brain. In lesions smaller than 0.2 mm2, the blood-brain barrier was intact. In the second, small diffuse nests of tumor cells were distributed throughout the brain parenchyma. The blood-brain barrier was intact until the small tumor cell colonies coalesced to form large tumor masses. These results suggest that the permeability of the blood-brain barrier varies among different experimental brain metastases and that its function is related to the growth pattern and size of the lesions. |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1886664</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>73344907</sourcerecordid><originalsourceid>FETCH-LOGICAL-h322t-b5e553fe8083ac6ba8295e39f253b0f2903479c3ae329db4831106a38916da163</originalsourceid><addsrcrecordid>eNpVkMuKFTEQhhtRxuPoIwhZiK4acj-djSDjFQbc6DpUuqunM-TSJt3qeQWf2sA5DAoFVeH76y_-POoOTHHVc2bY4-5AKeW9kZI-7Z7Vet-eWgz0qrtiUgoq9aH7897PMxZMm4dAViwRwfngtxPJM9kWJC7kPPWugE_EQSkeC2kj_m5iH9ti2zvTiBvUVljJWvK0jzgRdyLLHiGRhHkNUGMlPrYhbQ36tGWS9glJ9CM-757MECq-uPTr7vvHD99uPve3Xz99uXl32y-C8613CpUSMw50EDBqBwM3CoWZuRKOztxQIY9mFICCm8nJQTBGNYjBMD0B0-K6e3v2XXcXcRpbhALBri0NlJPN4O3_JPnF3uWflg2D1lo2g9cXg5J_7Fg3G30dMbRUmPdqj0JIaeixCV_-e-nhxOX3G3914VBHCHOBNPr6IJNKUWZUk705yxZ_t_zyBW2NEEIzZRbuVyaZVZYxpsRfc6Gfkg</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>73344907</pqid></control><display><type>article</type><title>Differential permeability of the blood-brain barrier in experimental brain metastases produced by human neoplasms implanted into nude mice</title><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><creator>Zhang, RD ; Price, JE ; Fujimaki, T ; Bucana, CD ; Fidler, IJ</creator><creatorcontrib>Zhang, RD ; Price, JE ; Fujimaki, T ; Bucana, CD ; Fidler, IJ</creatorcontrib><description>This study clarified whether and when the blood-brain barrier in experimental brain metastases is impaired by using hydrosoluble sodium fluorescein (MW 376) as a blood-brain barrier function indicator. Cells from eight human tumor lines (four melanomas, two breast carcinomas, one colon carcinoma, and one renal carcinoma) were inoculated into the internal carotid artery of nude mice. Brain metastases at different stages of development were sampled and the permeability of the blood-brain barrier around the metastases determined. Histologic examination showed two patterns of tumor growth. In the first, tumor cells formed isolated, well-defined nodules in the parenchyma of the brain. In lesions smaller than 0.2 mm2, the blood-brain barrier was intact. In the second, small diffuse nests of tumor cells were distributed throughout the brain parenchyma. The blood-brain barrier was intact until the small tumor cell colonies coalesced to form large tumor masses. These results suggest that the permeability of the blood-brain barrier varies among different experimental brain metastases and that its function is related to the growth pattern and size of the lesions.</description><identifier>ISSN: 0002-9440</identifier><identifier>EISSN: 1525-2191</identifier><identifier>PMID: 1443046</identifier><identifier>CODEN: AJPAA4</identifier><language>eng</language><publisher>Bethesda, MD: ASIP</publisher><subject>Animals ; Biological and medical sciences ; Blood-Brain Barrier - physiology ; Brain Neoplasms - pathology ; Brain Neoplasms - physiopathology ; Brain Neoplasms - secondary ; Breast Neoplasms - pathology ; Cell Membrane - physiology ; Cell Membrane - ultrastructure ; Cell Membrane Permeability - physiology ; Colonic Neoplasms - pathology ; Fluoresceins ; Humans ; Kidney Neoplasms - pathology ; Medical sciences ; Melanoma - pathology ; Mice ; Mice, Nude ; Neoplasm Transplantation ; Neurology ; Tumor Cells, Cultured</subject><ispartof>The American journal of pathology, 1992-11, Vol.141 (5), p.1115-1124</ispartof><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1886664/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1886664/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,53791,53793</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4550195$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1443046$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, RD</creatorcontrib><creatorcontrib>Price, JE</creatorcontrib><creatorcontrib>Fujimaki, T</creatorcontrib><creatorcontrib>Bucana, CD</creatorcontrib><creatorcontrib>Fidler, IJ</creatorcontrib><title>Differential permeability of the blood-brain barrier in experimental brain metastases produced by human neoplasms implanted into nude mice</title><title>The American journal of pathology</title><addtitle>Am J Pathol</addtitle><description>This study clarified whether and when the blood-brain barrier in experimental brain metastases is impaired by using hydrosoluble sodium fluorescein (MW 376) as a blood-brain barrier function indicator. Cells from eight human tumor lines (four melanomas, two breast carcinomas, one colon carcinoma, and one renal carcinoma) were inoculated into the internal carotid artery of nude mice. Brain metastases at different stages of development were sampled and the permeability of the blood-brain barrier around the metastases determined. Histologic examination showed two patterns of tumor growth. In the first, tumor cells formed isolated, well-defined nodules in the parenchyma of the brain. In lesions smaller than 0.2 mm2, the blood-brain barrier was intact. In the second, small diffuse nests of tumor cells were distributed throughout the brain parenchyma. The blood-brain barrier was intact until the small tumor cell colonies coalesced to form large tumor masses. These results suggest that the permeability of the blood-brain barrier varies among different experimental brain metastases and that its function is related to the growth pattern and size of the lesions.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Blood-Brain Barrier - physiology</subject><subject>Brain Neoplasms - pathology</subject><subject>Brain Neoplasms - physiopathology</subject><subject>Brain Neoplasms - secondary</subject><subject>Breast Neoplasms - pathology</subject><subject>Cell Membrane - physiology</subject><subject>Cell Membrane - ultrastructure</subject><subject>Cell Membrane Permeability - physiology</subject><subject>Colonic Neoplasms - pathology</subject><subject>Fluoresceins</subject><subject>Humans</subject><subject>Kidney Neoplasms - pathology</subject><subject>Medical sciences</subject><subject>Melanoma - pathology</subject><subject>Mice</subject><subject>Mice, Nude</subject><subject>Neoplasm Transplantation</subject><subject>Neurology</subject><subject>Tumor Cells, Cultured</subject><issn>0002-9440</issn><issn>1525-2191</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkMuKFTEQhhtRxuPoIwhZiK4acj-djSDjFQbc6DpUuqunM-TSJt3qeQWf2sA5DAoFVeH76y_-POoOTHHVc2bY4-5AKeW9kZI-7Z7Vet-eWgz0qrtiUgoq9aH7897PMxZMm4dAViwRwfngtxPJM9kWJC7kPPWugE_EQSkeC2kj_m5iH9ti2zvTiBvUVljJWvK0jzgRdyLLHiGRhHkNUGMlPrYhbQ36tGWS9glJ9CM-757MECq-uPTr7vvHD99uPve3Xz99uXl32y-C8613CpUSMw50EDBqBwM3CoWZuRKOztxQIY9mFICCm8nJQTBGNYjBMD0B0-K6e3v2XXcXcRpbhALBri0NlJPN4O3_JPnF3uWflg2D1lo2g9cXg5J_7Fg3G30dMbRUmPdqj0JIaeixCV_-e-nhxOX3G3914VBHCHOBNPr6IJNKUWZUk705yxZ_t_zyBW2NEEIzZRbuVyaZVZYxpsRfc6Gfkg</recordid><startdate>19921101</startdate><enddate>19921101</enddate><creator>Zhang, RD</creator><creator>Price, JE</creator><creator>Fujimaki, T</creator><creator>Bucana, CD</creator><creator>Fidler, IJ</creator><general>ASIP</general><general>American Society for Investigative Pathology</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19921101</creationdate><title>Differential permeability of the blood-brain barrier in experimental brain metastases produced by human neoplasms implanted into nude mice</title><author>Zhang, RD ; Price, JE ; Fujimaki, T ; Bucana, CD ; Fidler, IJ</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h322t-b5e553fe8083ac6ba8295e39f253b0f2903479c3ae329db4831106a38916da163</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Blood-Brain Barrier - physiology</topic><topic>Brain Neoplasms - pathology</topic><topic>Brain Neoplasms - physiopathology</topic><topic>Brain Neoplasms - secondary</topic><topic>Breast Neoplasms - pathology</topic><topic>Cell Membrane - physiology</topic><topic>Cell Membrane - ultrastructure</topic><topic>Cell Membrane Permeability - physiology</topic><topic>Colonic Neoplasms - pathology</topic><topic>Fluoresceins</topic><topic>Humans</topic><topic>Kidney Neoplasms - pathology</topic><topic>Medical sciences</topic><topic>Melanoma - pathology</topic><topic>Mice</topic><topic>Mice, Nude</topic><topic>Neoplasm Transplantation</topic><topic>Neurology</topic><topic>Tumor Cells, Cultured</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, RD</creatorcontrib><creatorcontrib>Price, JE</creatorcontrib><creatorcontrib>Fujimaki, T</creatorcontrib><creatorcontrib>Bucana, CD</creatorcontrib><creatorcontrib>Fidler, IJ</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The American journal of pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, RD</au><au>Price, JE</au><au>Fujimaki, T</au><au>Bucana, CD</au><au>Fidler, IJ</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Differential permeability of the blood-brain barrier in experimental brain metastases produced by human neoplasms implanted into nude mice</atitle><jtitle>The American journal of pathology</jtitle><addtitle>Am J Pathol</addtitle><date>1992-11-01</date><risdate>1992</risdate><volume>141</volume><issue>5</issue><spage>1115</spage><epage>1124</epage><pages>1115-1124</pages><issn>0002-9440</issn><eissn>1525-2191</eissn><coden>AJPAA4</coden><abstract>This study clarified whether and when the blood-brain barrier in experimental brain metastases is impaired by using hydrosoluble sodium fluorescein (MW 376) as a blood-brain barrier function indicator. Cells from eight human tumor lines (four melanomas, two breast carcinomas, one colon carcinoma, and one renal carcinoma) were inoculated into the internal carotid artery of nude mice. Brain metastases at different stages of development were sampled and the permeability of the blood-brain barrier around the metastases determined. Histologic examination showed two patterns of tumor growth. In the first, tumor cells formed isolated, well-defined nodules in the parenchyma of the brain. In lesions smaller than 0.2 mm2, the blood-brain barrier was intact. In the second, small diffuse nests of tumor cells were distributed throughout the brain parenchyma. The blood-brain barrier was intact until the small tumor cell colonies coalesced to form large tumor masses. These results suggest that the permeability of the blood-brain barrier varies among different experimental brain metastases and that its function is related to the growth pattern and size of the lesions.</abstract><cop>Bethesda, MD</cop><pub>ASIP</pub><pmid>1443046</pmid><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0002-9440 |
| ispartof | The American journal of pathology, 1992-11, Vol.141 (5), p.1115-1124 |
| issn | 0002-9440 1525-2191 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1886664 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Animals Biological and medical sciences Blood-Brain Barrier - physiology Brain Neoplasms - pathology Brain Neoplasms - physiopathology Brain Neoplasms - secondary Breast Neoplasms - pathology Cell Membrane - physiology Cell Membrane - ultrastructure Cell Membrane Permeability - physiology Colonic Neoplasms - pathology Fluoresceins Humans Kidney Neoplasms - pathology Medical sciences Melanoma - pathology Mice Mice, Nude Neoplasm Transplantation Neurology Tumor Cells, Cultured |
| title | Differential permeability of the blood-brain barrier in experimental brain metastases produced by human neoplasms implanted into nude mice |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-24T03%3A13%3A25IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Differential%20permeability%20of%20the%20blood-brain%20barrier%20in%20experimental%20brain%20metastases%20produced%20by%20human%20neoplasms%20implanted%20into%20nude%20mice&rft.jtitle=The%20American%20journal%20of%20pathology&rft.au=Zhang,%20RD&rft.date=1992-11-01&rft.volume=141&rft.issue=5&rft.spage=1115&rft.epage=1124&rft.pages=1115-1124&rft.issn=0002-9440&rft.eissn=1525-2191&rft.coden=AJPAA4&rft_id=info:doi/&rft_dat=%3Cproquest_pubme%3E73344907%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=73344907&rft_id=info:pmid/1443046&rfr_iscdi=true |