Modulation of keratinocyte-derived interleukin-8 which is chemotactic for neutrophils and T lymphocytes

Interactions between T lymphocytes, neutrophils, and epidermal cells are believed to play a central role in the pathophysiology of psoriasis and other inflammatory cutaneous disorders. Although there is strong evidence that lymphocyte-function-associated antigen-1 (LFA-1) positive T cells are retain...

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Veröffentlicht in:	The American journal of pathology 1991-10, Vol.139 (4), p.869-876
Hauptverfasser:	Barker, JN, Jones, ML, Mitra, RS, Crockett-Torabe, E, Fantone, JC, Kunkel, SL, Warren, JS, Dixit, VM, Nickoloff, BJ
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Blotting, Northern Cell Adhesion Molecules - genetics Cell Adhesion Molecules - metabolism Cells, Cultured Chemotaxis - drug effects Chemotaxis - physiology Cytokines - pharmacology Dermatology DNA - genetics Electrophoresis, Polyacrylamide Gel Fluorescent Antibody Technique Gene Expression - drug effects Humans Immunohistochemistry Intercellular Adhesion Molecule-1 Interleukin-8 - genetics Interleukin-8 - metabolism Interleukin-8 - physiology Keratinocytes - metabolism Lymphocyte Function-Associated Antigen-1 - genetics Lymphocyte Function-Associated Antigen-1 - metabolism Medical sciences Neutrophils - drug effects Neutrophils - physiology Precipitin Tests Psoriasis - metabolism RNA, Messenger - genetics T-Lymphocytes - drug effects T-Lymphocytes - physiology Tetradecanoylphorbol Acetate - pharmacology
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