Detection of Epstein-Barr virus sequences in Hodgkin's disease by the polymerase chain reaction
The authors examined paraffin-embedded lymph node biopsies from 65 cases of Hodgkin's disease for the presence of Epstein-Barr virus (EBV) DNA, using the highly sensitive polymerase chain reaction technique. Overall 40% of the cases were positive for EBV DNA; there were no statistically signifi...
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| Veröffentlicht in: | The American journal of pathology 1991-08, Vol.139 (2), p.393-398 |
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| container_title | The American journal of pathology |
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| creator | Wright, CF Reid, AH Tsai, MM Ventre, KM Murari, PJ Frizzera, G O'Leary, TJ |
| description | The authors examined paraffin-embedded lymph node biopsies from 65 cases of Hodgkin's disease for the presence of Epstein-Barr virus (EBV) DNA, using the highly sensitive polymerase chain reaction technique. Overall 40% of the cases were positive for EBV DNA; there were no statistically significant differences in the frequency of EBV positivity among the different subtypes of Hodgkin's disease. These results are in agreement with those of previous studies that employed less sensitive detection techniques and suggest that EBV either is present in pathologic tissues only in some phases of the evolution of Hodgkin's disease or is a pathogenetic factor involved in only a portion of cases. |
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Overall 40% of the cases were positive for EBV DNA; there were no statistically significant differences in the frequency of EBV positivity among the different subtypes of Hodgkin's disease. These results are in agreement with those of previous studies that employed less sensitive detection techniques and suggest that EBV either is present in pathologic tissues only in some phases of the evolution of Hodgkin's disease or is a pathogenetic factor involved in only a portion of cases.</description><identifier>ISSN: 0002-9440</identifier><identifier>EISSN: 1525-2191</identifier><identifier>PMID: 1651058</identifier><identifier>CODEN: AJPAA4</identifier><language>eng</language><publisher>Bethesda, MD: ASIP</publisher><subject>Biological and medical sciences ; Biopsy ; DNA, Viral - analysis ; Gene Amplification ; Hematologic and hematopoietic diseases ; Herpesvirus 4, Human - genetics ; Hodgkin Disease - classification ; Hodgkin Disease - genetics ; Humans ; Hyperplasia ; Lymph Nodes - metabolism ; Lymph Nodes - pathology ; Medical sciences ; Polymerase Chain Reaction</subject><ispartof>The American journal of pathology, 1991-08, Vol.139 (2), p.393-398</ispartof><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1886073/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1886073/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,53766,53768</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4470167$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1651058$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wright, CF</creatorcontrib><creatorcontrib>Reid, AH</creatorcontrib><creatorcontrib>Tsai, MM</creatorcontrib><creatorcontrib>Ventre, KM</creatorcontrib><creatorcontrib>Murari, PJ</creatorcontrib><creatorcontrib>Frizzera, G</creatorcontrib><creatorcontrib>O'Leary, TJ</creatorcontrib><title>Detection of Epstein-Barr virus sequences in Hodgkin's disease by the polymerase chain reaction</title><title>The American journal of pathology</title><addtitle>Am J Pathol</addtitle><description>The authors examined paraffin-embedded lymph node biopsies from 65 cases of Hodgkin's disease for the presence of Epstein-Barr virus (EBV) DNA, using the highly sensitive polymerase chain reaction technique. Overall 40% of the cases were positive for EBV DNA; there were no statistically significant differences in the frequency of EBV positivity among the different subtypes of Hodgkin's disease. These results are in agreement with those of previous studies that employed less sensitive detection techniques and suggest that EBV either is present in pathologic tissues only in some phases of the evolution of Hodgkin's disease or is a pathogenetic factor involved in only a portion of cases.</description><subject>Biological and medical sciences</subject><subject>Biopsy</subject><subject>DNA, Viral - analysis</subject><subject>Gene Amplification</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Herpesvirus 4, Human - genetics</subject><subject>Hodgkin Disease - classification</subject><subject>Hodgkin Disease - genetics</subject><subject>Humans</subject><subject>Hyperplasia</subject><subject>Lymph Nodes - metabolism</subject><subject>Lymph Nodes - pathology</subject><subject>Medical sciences</subject><subject>Polymerase Chain Reaction</subject><issn>0002-9440</issn><issn>1525-2191</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkMtOwzAQRSMEgvL4BCQvEKwieezEcTZIUMpDqsSGvTVJJ40hcYKdFvXvSaHisRrN3KtzZ2YvmkAq0lhADvvRhHMu4jxJ-FF0HMLr2Cqp-WF0CCoFnupJZO5ooHKwnWNdxWZ9GMi6-Ba9Z2vrV4EFel-RKykw69hjt1i-WXcV2MIGwkCs2LChJtZ3zaYlv52UNY5OT_hFPY0OKmwCne3qSfRyP3uZPsbz54en6c08rqWAISYQwAUUXORaa57pVGfAMalSvkiVpFxSBVkuOCghhMqLpKhIoVJFVVYI8iS6_sb2q6KlRUlu8NiY3tsW_cZ0aM1_xdnaLLu1Aa0Vz-QIuNwBfDceHAbT2lBS06CjbhXMuJMEgK3x_G_ST8Tuo6N-sdMxlNhUHl1pw48tSbLxhuw3r7bL-sN6MqHFphmhYPC1B5kbYWQu5ScjSY2j</recordid><startdate>19910801</startdate><enddate>19910801</enddate><creator>Wright, CF</creator><creator>Reid, AH</creator><creator>Tsai, MM</creator><creator>Ventre, KM</creator><creator>Murari, PJ</creator><creator>Frizzera, G</creator><creator>O'Leary, TJ</creator><general>ASIP</general><general>American Society for Investigative Pathology</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19910801</creationdate><title>Detection of Epstein-Barr virus sequences in Hodgkin's disease by the polymerase chain reaction</title><author>Wright, CF ; Reid, AH ; Tsai, MM ; Ventre, KM ; Murari, PJ ; Frizzera, G ; O'Leary, TJ</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h321t-e121021b02988807858710a4f50d563e93ef179201622269b4bfe6a66bfcfa13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Biological and medical sciences</topic><topic>Biopsy</topic><topic>DNA, Viral - analysis</topic><topic>Gene Amplification</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Herpesvirus 4, Human - genetics</topic><topic>Hodgkin Disease - classification</topic><topic>Hodgkin Disease - genetics</topic><topic>Humans</topic><topic>Hyperplasia</topic><topic>Lymph Nodes - metabolism</topic><topic>Lymph Nodes - pathology</topic><topic>Medical sciences</topic><topic>Polymerase Chain Reaction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wright, CF</creatorcontrib><creatorcontrib>Reid, AH</creatorcontrib><creatorcontrib>Tsai, MM</creatorcontrib><creatorcontrib>Ventre, KM</creatorcontrib><creatorcontrib>Murari, PJ</creatorcontrib><creatorcontrib>Frizzera, G</creatorcontrib><creatorcontrib>O'Leary, TJ</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The American journal of pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wright, CF</au><au>Reid, AH</au><au>Tsai, MM</au><au>Ventre, KM</au><au>Murari, PJ</au><au>Frizzera, G</au><au>O'Leary, TJ</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Detection of Epstein-Barr virus sequences in Hodgkin's disease by the polymerase chain reaction</atitle><jtitle>The American journal of pathology</jtitle><addtitle>Am J Pathol</addtitle><date>1991-08-01</date><risdate>1991</risdate><volume>139</volume><issue>2</issue><spage>393</spage><epage>398</epage><pages>393-398</pages><issn>0002-9440</issn><eissn>1525-2191</eissn><coden>AJPAA4</coden><abstract>The authors examined paraffin-embedded lymph node biopsies from 65 cases of Hodgkin's disease for the presence of Epstein-Barr virus (EBV) DNA, using the highly sensitive polymerase chain reaction technique. Overall 40% of the cases were positive for EBV DNA; there were no statistically significant differences in the frequency of EBV positivity among the different subtypes of Hodgkin's disease. These results are in agreement with those of previous studies that employed less sensitive detection techniques and suggest that EBV either is present in pathologic tissues only in some phases of the evolution of Hodgkin's disease or is a pathogenetic factor involved in only a portion of cases.</abstract><cop>Bethesda, MD</cop><pub>ASIP</pub><pmid>1651058</pmid><tpages>6</tpages></addata></record> |
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| ispartof | The American journal of pathology, 1991-08, Vol.139 (2), p.393-398 |
| issn | 0002-9440 1525-2191 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Biological and medical sciences Biopsy DNA, Viral - analysis Gene Amplification Hematologic and hematopoietic diseases Herpesvirus 4, Human - genetics Hodgkin Disease - classification Hodgkin Disease - genetics Humans Hyperplasia Lymph Nodes - metabolism Lymph Nodes - pathology Medical sciences Polymerase Chain Reaction |
| title | Detection of Epstein-Barr virus sequences in Hodgkin's disease by the polymerase chain reaction |
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