Physiological Expression of the Gene for PrP-Like Protein, PrPLP/Dpl, by Brain Endothelial Cells and its Ectopic Expression in Neurons of PrP-Deficient Mice Ataxic Due to Purkinje Cell Degeneration

Recently, a novel gene encoding a prion protein (PrP)-like glycoprotein, PrPLP/Dpl, was identified as being expressed ectopically by neurons of the ataxic PrP-deficient ( Prnp −/−) mouse lines exhibiting Purkinje cell degeneration. In adult wild-type mice, PrPLP/Dpl mRNA was physiologically expresse...

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Veröffentlicht in:	The American journal of pathology 2000-11, Vol.157 (5), p.1447-1452
Hauptverfasser:	Li, Aimin, Sakaguchi, Suehiro, Shigematsu, Kazuto, Atarashi, Ryuichiro, Roy, Bhabesh C., Nakaoke, Ryota, Arima, Kazuhiko, Okimura, Nobuhiko, Kopacek, Juraj, Katamine, Shigeru
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphatases Animals Ataxia - etiology Ataxia - genetics Biological and medical sciences Cerebrovascular Circulation - physiology Endothelium, Vascular - cytology Endothelium, Vascular - physiology Experimental viral diseases and models Fungal Proteins Gene Expression GPI-Linked Proteins Infectious diseases Medical sciences Mice Mice, Mutant Strains Nerve Degeneration - complications Neurons - physiology Prions - genetics Prions - metabolism Purkinje Cells - physiology RNA Helicases RNA Splicing Factors Saccharomyces cerevisiae Proteins Short Communications Viral diseases
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