Crystal structure of the third KH domain of human poly(C)-binding protein-2 in complex with a C-rich strand of human telomeric DNA at 1.6 Å resolution

KH (hnRNP K homology) domains, consisting of ~70 amino acid residues, are present in a variety of nucleic-acid-binding proteins. Among these are poly(C)-binding proteins (PCBPs), which are important regulators of mRNA stability and posttranscriptional regulation in general. All PCBPs contain three d...

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Veröffentlicht in:	Nucleic acids research 2007, Vol.35 (8), p.2651-2660
Hauptverfasser:	Fenn, Sebastian, Du, Zhihua, Lee, John K, Tjhen, Richard, Stroud, Robert M, James, Thomas L
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Binding Sites Crystallography, X-Ray DNA - chemistry Humans Hydrogen Bonding Models, Molecular Molecular Sequence Data Protein Structure, Tertiary RNA-Binding Proteins - chemistry Sequence Alignment Structural Biology Telomere - chemistry
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