Expansion of spleen myeloid suppressor cells represses NK cell cytotoxicity in tumor-bearing host

Tumor growth promotes the expansion of myeloid suppressor cells. An inverse correlation between natural killer (NK) cell activation and myeloid suppressor cell (MSC) expansion in tumor-bearing patients and mice prompted us to investigate the role of MSCs in controlling NK antitumor cytotocixity. Aft...

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Veröffentlicht in:	Blood 2007-05, Vol.109 (10), p.4336-4342
Hauptverfasser:	Liu, Cunren, Yu, Shaohua, Kappes, John, Wang, Jianhua, Grizzle, William E., Zinn, Kurt R., Zhang, Huang-Ge
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - immunology Animals Biological and medical sciences CD11b Antigen - metabolism Cell Adhesion - immunology Cell Proliferation Cells, Cultured Cytotoxicity, Immunologic Female Host-tumor relations. Immunology. Biological markers Immunobiology Interleukin-2 - pharmacology Killer Cells, Natural - immunology Mammary Neoplasms, Animal - immunology Medical sciences Membrane Glycoproteins - metabolism Mice Mice, Inbred BALB C Perforin Pore Forming Cytotoxic Proteins - metabolism Receptors, Chemokine - metabolism Spleen - cytology Spleen - drug effects STAT5 Transcription Factor - metabolism T-Lymphocytes, Regulatory - cytology T-Lymphocytes, Regulatory - drug effects T-Lymphocytes, Regulatory - metabolism T-Lymphocytes, Regulatory - physiology Tumors
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