Syndecan-4-dependent Rac1 regulation determines directional migration in response to the extracellular matrix

Cell migration in wound healing and disease is critically dependent on integration with the extracellular matrix, but the receptors that couple matrix topography to migratory behavior remain obscure. Using nano-engineered fibronectin surfaces and cell-derived matrices, we identify syndecan-4 as a ke...

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Veröffentlicht in:	The Journal of cell biology 2007-05, Vol.177 (3), p.527-538
Hauptverfasser:	Bass, Mark D, Roach, Kirsty A, Morgan, Mark R, Mostafavi-Pour, Zohreh, Schoen, Tobias, Muramatsu, Takashi, Mayer, Ulrike, Ballestrem, Christoph, Spatz, Joachim P, Humphries, Martin J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biochemistry Cell adhesion Cell adhesion & migration Cell lines Cell Movement - genetics Cells, Cultured Enzyme Activation - genetics Extracellular Matrix Fibroblasts Fibroblasts - cytology Fibroblasts - metabolism Fibronectins Fibrosis Focal adhesions Glycoproteins Integrins Kinases Ligands Membranes Mice Mice, Knockout Mutation Neuropeptides - genetics Neuropeptides - metabolism Physiological regulation Protein Kinase C-alpha - deficiency Protein Kinase C-alpha - metabolism Protein Structure, Tertiary - genetics rac GTP-Binding Proteins - genetics rac GTP-Binding Proteins - metabolism rac1 GTP-Binding Protein Receptors Stripes Syndecan-4 - genetics Syndecan-4 - metabolism Wound healing
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