Synthesis and evaluation of isosteres of N-methyl indolo[3,2- b]-quinoline (cryptolepine) as new antiinfective agents

Isosteres of cryptolepine ( 1) were synthesized and evaluated for their antiinfective activities. Overall, the sulfur isostere, 5-methyl benzothieno[3,2- b]quinolinium salt ( 5b), was equipotent to 1 and has shown no cytotoxicity at 23.8 μg/mL. Compound 5b was also found to have a broad spectrum of...

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