Autotaxin is released from adipocytes, catalyzes lysophosphatidic acid synthesis, and activates preadipocyte proliferation. Up-regulated expression with adipocyte differentiation and obesity

Our group has recently demonstrated (Gesta, S., Simon, M., Rey, A., Sibrac, D., Girard, A., Lafontan, M., Valet, P., and Saulnier-Blache, J. S. (2002) J. Lipid Res. 43, 904-910) the presence, in adipocyte conditioned-medium, of a soluble lysophospholipase d-activity (LPLDact) involved in synthesis o...

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Veröffentlicht in:	The Journal of biological chemistry 2003-05, Vol.278 (20), p.18162-18169
Hauptverfasser:	Ferry, Gilles, Tellier, Edwige, Try, Anne, Grés, Sandra, Naime, Isabelle, Simon, Marie Françoise, Rodriguez, Marianne, Boucher, Jérémie, Tack, Ivan, Gesta, Stéphane, Chomarat, Pascale, Dieu, Marc, Raes, Martine, Galizzi, Jean Pierre, Valet, Philippe, Boutin, Jean A, Saulnier-Blache, Jean Sébastien
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipocytes Adipocytes - metabolism Amino Acid Sequence Animals Autocrine Motility Factor Cell Differentiation Cell Division Cellular Biology Cloning, Molecular COS Cells Culture Media, Conditioned Culture Media, Conditioned - pharmacology Databases as Topic DNA, Complementary DNA, Complementary - metabolism Electrophoresis, Polyacrylamide Gel Glucose-6-Phosphate Isomerase - chemistry Glucose-6-Phosphate Isomerase - metabolism Glycoproteins Glycoproteins - chemistry Glycoproteins - metabolism Life Sciences Lysopho Lysophospholipids - metabolism Male Mass Spectrometry Mice Mice, Inbred C57BL Molecular Sequence Data Multienzyme Complexes Phosphodiesterase I Phosphoric Diester Hydrolases - metabolism Pyrophosphatases Recombinant Proteins - metabolism Reverse Transcriptase Polymerase Chain Reaction RNA - metabolism RNA, Messenger - metabolism Time Factors Transfection Up-Regulation
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