Developmental exposure of mice to TCDD elicits a similar uterine phenotype in adult animals as observed in women with endometriosis

Whether environmental toxicants impact an individual woman's risk for developing endometriosis remains uncertain. Although the growth of endometrial glands and stroma at extra-uterine sites is associated with retrograde menstruation, our studies suggest that reduced responsiveness to progestero...

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Veröffentlicht in:	Reproductive toxicology (Elmsford, N.Y.) N.Y.), 2007-04, Vol.23 (3), p.326-336
Hauptverfasser:	Nayyar, Tultul, Bruner-Tran, Kaylon L., Piestrzeniewicz-Ulanska, Dagmara, Osteen, Kevin G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blotting, Western Cytochrome P-450 CYP1A1 - metabolism Development Dioxin Disease Models, Animal Endometriosis Endometriosis - metabolism Endometriosis - pathology Endometrium Endometrium - drug effects Endometrium - metabolism Endometrium - pathology Environmental Pollutants - poisoning Estradiol - pharmacology Female Fetal origin Humans Immunohistochemistry Liver - drug effects Liver - metabolism Liver - pathology Male Mice Mice, Inbred C57BL Organ Culture Techniques Ovariectomy Polychlorinated Dibenzodioxins - poisoning Pregnancy Progesterone Progesterone - pharmacology Progesterone receptor Receptors, Progesterone - metabolism Sex Factors TCDD TGF-β2 Transforming Growth Factor beta2 - metabolism Uterus - drug effects Uterus - metabolism Uterus - pathology
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