Effects of lasofoxifene on the pharmacokinetics and pharmacodynamics of single‐dose warfarin

Aim To investigate the effect of steady‐state lasofoxifene on the pharmacokinetics and pharmacodynamics of warfarin. Methods Twelve healthy postmenopausal women received warfarin (single 20‐mg dose) alone and during lasofoxifene. R‐ and S‐warfarin concentrations, prothrombin time (PT) and internatio...

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Veröffentlicht in:	British journal of clinical pharmacology 2006-06, Vol.61 (6), p.741-745
Hauptverfasser:	Ouellet, Daniele, Bramson, Candace, Carvajal‐Gonzalez, Santos, Roman, Doina, Randinitis, Edward, Remmers, Ann, Gardner, Mark J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Anticoagulants - administration & dosage Anticoagulants - blood Anticoagulants - pharmacokinetics Area Under Curve Aryl Hydrocarbon Hydroxylases - genetics Biological and medical sciences Cross-Over Studies Cytochrome P-450 CYP2C9 drug interaction Female Genotype Heterozygote Humans International Normalized Ratio lasofoxifene Medical sciences Middle Aged Mutation - genetics Original pharmacodynamics pharmacokinetics Pharmacology. Drug treatments Postmenopause Prothrombin Time Pyrrolidines - pharmacology Tetrahydronaphthalenes - pharmacology warfarin Warfarin - administration & dosage Warfarin - blood Warfarin - pharmacokinetics
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