Effect of ginkgo and ginger on the pharmacokinetics and pharmacodynamics of warfarin in healthy subjects

Aim The aim of this study was to investigate the effect of two common herbal medicines, ginkgo and ginger, on the pharmacokinetics and pharmacodynamics of warfarin and the independent effect of these herbs on clotting status. Methods This was an open label, three‐way crossover randomized study in 12...

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Veröffentlicht in:	British journal of clinical pharmacology 2005-04, Vol.59 (4), p.425-432
Hauptverfasser:	Jiang, Xuemin, Williams, Kenneth M., Liauw, Winston S., Ammit, Alaina J., Roufogalis, Basil D., Duke, Colin C., Day, Richard O., McLachlan, Andrew J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Adult anticoagulants Anticoagulants - pharmacokinetics Anticoagulants - pharmacology Area Under Curve Biological and medical sciences Cross-Over Studies Drug Interactions ginger ginkgo Ginkgo biloba - metabolism Herb-Drug Interactions Humans International Normalized Ratio Male Medical sciences Pharmacology. Drug treatments Platelet Aggregation - drug effects Protein Binding - drug effects warfarin Warfarin - pharmacokinetics Warfarin - pharmacology Zingiber officinale - metabolism
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