MFG-E8-mediated uptake of apoptotic cells by APCs links the pro- and antiinflammatory activities of GM-CSF

Granulocyte-macrophage colony-stimulating factor (GM-CSF) enhances protection against tumors and infections, but GM-CSF-deficient mice develop inflammatory disease. Here we show that GM-CSF is required for the expression of milk fat globule EGF 8 (MFG-E8) in antigen-presenting cells, and that MFG-E8...

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Veröffentlicht in:	The Journal of clinical investigation 2007-07, Vol.117 (7), p.1902-1913
Hauptverfasser:	Jinushi, Masahisa, Nakazaki, Yukoh, Dougan, Michael, Carrasco, Daniel R, Mihm, Martin, Dranoff, Glenn
Format:	Artikel
Sprache:	eng
Schlagworte:	Ablation Animals Antigen-Presenting Cells - cytology Antigen-Presenting Cells - metabolism Antigens Antigens, Surface - metabolism Apoptosis Biomedical research Bone marrow Cancer cells Cancer Vaccines Care and treatment CD4-Positive T-Lymphocytes - cytology CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - metabolism Cell Differentiation Complications and side effects Cytokines Dendritic cells Gene Expression Regulation Granulocyte-macrophage colony stimulating factor Granulocyte-Macrophage Colony-Stimulating Factor - deficiency Granulocyte-Macrophage Colony-Stimulating Factor - genetics Granulocyte-Macrophage Colony-Stimulating Factor - metabolism Granulocyte-Macrophage Colony-Stimulating Factor - secretion Granulocytes Homeostasis Immunotherapy Inflammation Inflammation - genetics Inflammation - metabolism Inflammation - pathology Kinases Ligands Lymphocytes Mice Mice, Inbred C57BL Mice, Knockout Milk Milk Proteins - metabolism Neoplasms - immunology Neoplasms - metabolism Neoplasms - pathology Neoplasms - therapy Oils & fats Pathology Phagocytosis Surfactants Tumors
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