The CYP2C8 inhibitor trimethoprim increases the plasma concentrations of repaglinide in healthy subjects

Aims Our aim was to investigate the effect of the CYP2C8 inhibitor trimethoprim on the pharmacokinetics and pharmacodynamics of the antidiabetic drug repaglinide, and to examine the influence of the former on the metabolism of the latter in vitro. Methods In a randomized, double‐blind, crossover stu...

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Veröffentlicht in:	British journal of clinical pharmacology 2004-04, Vol.57 (4), p.441-447
Hauptverfasser:	Niemi, Mikko, Kajosaari, Lauri I., Neuvonen, Mikko, Backman, Janne T., Neuvonen, Pertti J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aryl Hydrocarbon Hydroxylases - antagonists & inhibitors Biological and medical sciences Biotransformation Carbamates - blood Carbamates - pharmacokinetics Cross-Over Studies CYP2C8 Cytochrome P-450 CYP2C8 Diabetes Mellitus - drug therapy Double-Blind Method drug interaction Drug Interactions Female General and cellular metabolism. Vitamins Humans Hypoglycemic Agents - blood Hypoglycemic Agents - pharmacokinetics Male Medical sciences Pharmacology. Drug treatments Piperidines - blood Piperidines - pharmacokinetics repaglinide trimethoprim Trimethoprim - pharmacology
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