Pharmacokinetic properties of zolpidem in elderly and young adults: possible modulation by testosterone in men

Aims The influence of ageing on the pharmacokinetics of zolpidem, an extensively prescribed hypnotic medication, was evaluated in healthy human volunteers. Methods A series of 16 elderly (age: 61–85 years) and 24 young (age: 22–42 years) volunteers received single 5 mg oral doses of zolpidem tartr...

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Veröffentlicht in:	British journal of clinical pharmacology 2003-09, Vol.56 (3), p.297-304
Hauptverfasser:	Olubodun, Joel O., Ochs, Hermann R., Von Moltke, Lisa L., Roubenoff, Ronenn, Hesse, Leah M., Harmatz, Jerold S., Shader, Richard I., Greenblatt, David J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Adult Aged Aged, 80 and over ageing Aging - physiology Biological and medical sciences Chromatography, High Pressure Liquid Drug Interactions Female GABA Agonists - administration & dosage GABA Agonists - blood GABA Agonists - pharmacokinetics Half-Life Hepatocytes - drug effects Humans Hypnotics and Sedatives - administration & dosage Hypnotics and Sedatives - blood Hypnotics and Sedatives - pharmacokinetics Hypnotics. Sedatives Male Medical sciences Microsomes, Liver - drug effects Middle Aged Neuropharmacology pharmacokinetics Pharmacokinetics and Drug Disposition Pharmacology. Drug treatments Psychology. Psychoanalysis. Psychiatry Psychopharmacology Pyridines - administration & dosage Pyridines - blood Pyridines - pharmacokinetics testosterone Testosterone - physiology Zolpidem
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