Replacement therapy for vitamin B12 deficiency: comparison between the sublingual and oral route
Aims To compare the efficacy of sublingual and oral administration of 500 µg of cobalamin in subjects with cobalamin deficiency. Materials and results Thirty subjects with low serum concentrations of cobalamin participated in the study. Subjects were randomly allocated to receive one tablet daily...
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| Veröffentlicht in: | British journal of clinical pharmacology 2003-12, Vol.56 (6), p.635-638 |
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| creator | Sharabi, Amir Cohen, Eytan Sulkes, Jaqueline Garty, Moshe |
| description | Aims To compare the efficacy of sublingual and oral administration of 500 µg of cobalamin in subjects with cobalamin deficiency.
Materials and results Thirty subjects with low serum concentrations of cobalamin participated in the study. Subjects were randomly allocated to receive one tablet daily of 500 µg cobalamin sublingually or orally, or two tablets daily of a vitamin B complex. Serum cobalamin concentrations before treatment were 94 ± 30 pmol l−1, 108 ± 17 pmol l−1 and 98 ± 14 pmol l−1 in the sublingual B12, oral B12 and oral B‐complex groups, respectively. After 4 weeks, concentrations rose to 288 ± 74 pmol l−1, 286 ± 87 pmol l−1 and 293 ± 78 pmol l−1, respectively. The increase in each group across time was statistically significant (P = 0.0001, differences [95% confidence intervals] 194.2 (114.5, 273.9), 178.3 (104.2, 252.4), and 195.1 (135.0, 255.2) pmol l−1, respectively). There was no significant difference in concentrations between the treatment groups.
Conclusion A dose of 500 µg of cobalamin given either sublingually or orally is effective in correcting cobalamin deficiency. |
| doi_str_mv | 10.1046/j.1365-2125.2003.01907.x |
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Materials and results Thirty subjects with low serum concentrations of cobalamin participated in the study. Subjects were randomly allocated to receive one tablet daily of 500 µg cobalamin sublingually or orally, or two tablets daily of a vitamin B complex. Serum cobalamin concentrations before treatment were 94 ± 30 pmol l−1, 108 ± 17 pmol l−1 and 98 ± 14 pmol l−1 in the sublingual B12, oral B12 and oral B‐complex groups, respectively. After 4 weeks, concentrations rose to 288 ± 74 pmol l−1, 286 ± 87 pmol l−1 and 293 ± 78 pmol l−1, respectively. The increase in each group across time was statistically significant (P = 0.0001, differences [95% confidence intervals] 194.2 (114.5, 273.9), 178.3 (104.2, 252.4), and 195.1 (135.0, 255.2) pmol l−1, respectively). There was no significant difference in concentrations between the treatment groups.
Conclusion A dose of 500 µg of cobalamin given either sublingually or orally is effective in correcting cobalamin deficiency.</description><identifier>ISSN: 0306-5251</identifier><identifier>EISSN: 1365-2125</identifier><identifier>DOI: 10.1046/j.1365-2125.2003.01907.x</identifier><identifier>PMID: 14616423</identifier><identifier>CODEN: BCPHBM</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Science Ltd</publisher><subject>Administration, Oral ; Administration, Sublingual ; Biological and medical sciences ; cobalamin deficiency ; Cystamine - analogs & derivatives ; Cystamine - blood ; General and cellular metabolism. Vitamins ; Humans ; Medical sciences ; Middle Aged ; oral ; Pharmacokinetics ; Pharmacology. Drug treatments ; Schilling Test ; sublingual ; Treatment Outcome ; Vitamin B 12 - administration & dosage ; Vitamin B 12 Deficiency - blood ; Vitamin B 12 Deficiency - drug therapy</subject><ispartof>British journal of clinical pharmacology, 2003-12, Vol.56 (6), p.635-638</ispartof><rights>2004 INIST-CNRS</rights><rights>2003 Blackwell Publishing Ltd 2003</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5007-fdb3e17d6a260ab498e5cbb34d9081a4e07524c1e6f51e39d777a787990e43143</citedby><cites>FETCH-LOGICAL-c5007-fdb3e17d6a260ab498e5cbb34d9081a4e07524c1e6f51e39d777a787990e43143</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1046%2Fj.1365-2125.2003.01907.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1046%2Fj.1365-2125.2003.01907.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,778,782,883,1414,1430,27911,27912,45561,45562,46396,46820</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15788886$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14616423$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sharabi, Amir</creatorcontrib><creatorcontrib>Cohen, Eytan</creatorcontrib><creatorcontrib>Sulkes, Jaqueline</creatorcontrib><creatorcontrib>Garty, Moshe</creatorcontrib><title>Replacement therapy for vitamin B12 deficiency: comparison between the sublingual and oral route</title><title>British journal of clinical pharmacology</title><addtitle>Br J Clin Pharmacol</addtitle><description>Aims To compare the efficacy of sublingual and oral administration of 500 µg of cobalamin in subjects with cobalamin deficiency.
Materials and results Thirty subjects with low serum concentrations of cobalamin participated in the study. Subjects were randomly allocated to receive one tablet daily of 500 µg cobalamin sublingually or orally, or two tablets daily of a vitamin B complex. Serum cobalamin concentrations before treatment were 94 ± 30 pmol l−1, 108 ± 17 pmol l−1 and 98 ± 14 pmol l−1 in the sublingual B12, oral B12 and oral B‐complex groups, respectively. After 4 weeks, concentrations rose to 288 ± 74 pmol l−1, 286 ± 87 pmol l−1 and 293 ± 78 pmol l−1, respectively. The increase in each group across time was statistically significant (P = 0.0001, differences [95% confidence intervals] 194.2 (114.5, 273.9), 178.3 (104.2, 252.4), and 195.1 (135.0, 255.2) pmol l−1, respectively). There was no significant difference in concentrations between the treatment groups.
Conclusion A dose of 500 µg of cobalamin given either sublingually or orally is effective in correcting cobalamin deficiency.</description><subject>Administration, Oral</subject><subject>Administration, Sublingual</subject><subject>Biological and medical sciences</subject><subject>cobalamin deficiency</subject><subject>Cystamine - analogs & derivatives</subject><subject>Cystamine - blood</subject><subject>General and cellular metabolism. Vitamins</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>oral</subject><subject>Pharmacokinetics</subject><subject>Pharmacology. Drug treatments</subject><subject>Schilling Test</subject><subject>sublingual</subject><subject>Treatment Outcome</subject><subject>Vitamin B 12 - administration & dosage</subject><subject>Vitamin B 12 Deficiency - blood</subject><subject>Vitamin B 12 Deficiency - drug therapy</subject><issn>0306-5251</issn><issn>1365-2125</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkUFv1DAQhS0EokvhLyBf4JbUE9txggQSXUFBqgRCcDaOM2m9SuxgJ23335OwqxZu-OKR5r2ZZ3-EUGA5MFGe7XLgpcwKKGReMMZzBjVT-d0jsrlvPCYbxlmZyULCCXmW0o4x4FDKp-QERAmlKPiG_PyGY28sDugnOl1jNOOediHSGzeZwXl6DgVtsXPWobf7N9SGYTTRpeBpg9Mtol9tNM1N7_zVbHpqfEtDXIoY5gmfkyed6RO-ON6n5MfHD9-3n7LLLxeft-8vMysZU1nXNhxBtaUpSmYaUVcobdNw0dasAiOQKVkIC1h2EpDXrVLKqErVNUPBQfBT8u4wd5ybAVu7vGfJoMfoBhP3Ohin_-14d62vwo2GqhKc8WXA6-OAGH7NmCY9uGSx743HMCetgKti-d1FWB2ENoaUInb3S4DpFY_e6ZWCXinoFY_-g0ffLdaXf4d8MB55LIJXR4FJ1vRdNN669KCTqlrOmuHtQXfretz_dwB9vv26Vvw3B8GsnA</recordid><startdate>200312</startdate><enddate>200312</enddate><creator>Sharabi, Amir</creator><creator>Cohen, Eytan</creator><creator>Sulkes, Jaqueline</creator><creator>Garty, Moshe</creator><general>Blackwell Science Ltd</general><general>Blackwell Science</general><general>Blackwell Science Inc</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>200312</creationdate><title>Replacement therapy for vitamin B12 deficiency: comparison between the sublingual and oral route</title><author>Sharabi, Amir ; Cohen, Eytan ; Sulkes, Jaqueline ; Garty, Moshe</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5007-fdb3e17d6a260ab498e5cbb34d9081a4e07524c1e6f51e39d777a787990e43143</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Administration, Oral</topic><topic>Administration, Sublingual</topic><topic>Biological and medical sciences</topic><topic>cobalamin deficiency</topic><topic>Cystamine - analogs & derivatives</topic><topic>Cystamine - blood</topic><topic>General and cellular metabolism. Vitamins</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>oral</topic><topic>Pharmacokinetics</topic><topic>Pharmacology. Drug treatments</topic><topic>Schilling Test</topic><topic>sublingual</topic><topic>Treatment Outcome</topic><topic>Vitamin B 12 - administration & dosage</topic><topic>Vitamin B 12 Deficiency - blood</topic><topic>Vitamin B 12 Deficiency - drug therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sharabi, Amir</creatorcontrib><creatorcontrib>Cohen, Eytan</creatorcontrib><creatorcontrib>Sulkes, Jaqueline</creatorcontrib><creatorcontrib>Garty, Moshe</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>British journal of clinical pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sharabi, Amir</au><au>Cohen, Eytan</au><au>Sulkes, Jaqueline</au><au>Garty, Moshe</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Replacement therapy for vitamin B12 deficiency: comparison between the sublingual and oral route</atitle><jtitle>British journal of clinical pharmacology</jtitle><addtitle>Br J Clin Pharmacol</addtitle><date>2003-12</date><risdate>2003</risdate><volume>56</volume><issue>6</issue><spage>635</spage><epage>638</epage><pages>635-638</pages><issn>0306-5251</issn><eissn>1365-2125</eissn><coden>BCPHBM</coden><abstract>Aims To compare the efficacy of sublingual and oral administration of 500 µg of cobalamin in subjects with cobalamin deficiency.
Materials and results Thirty subjects with low serum concentrations of cobalamin participated in the study. Subjects were randomly allocated to receive one tablet daily of 500 µg cobalamin sublingually or orally, or two tablets daily of a vitamin B complex. Serum cobalamin concentrations before treatment were 94 ± 30 pmol l−1, 108 ± 17 pmol l−1 and 98 ± 14 pmol l−1 in the sublingual B12, oral B12 and oral B‐complex groups, respectively. After 4 weeks, concentrations rose to 288 ± 74 pmol l−1, 286 ± 87 pmol l−1 and 293 ± 78 pmol l−1, respectively. The increase in each group across time was statistically significant (P = 0.0001, differences [95% confidence intervals] 194.2 (114.5, 273.9), 178.3 (104.2, 252.4), and 195.1 (135.0, 255.2) pmol l−1, respectively). There was no significant difference in concentrations between the treatment groups.
Conclusion A dose of 500 µg of cobalamin given either sublingually or orally is effective in correcting cobalamin deficiency.</abstract><cop>Oxford, UK</cop><pub>Blackwell Science Ltd</pub><pmid>14616423</pmid><doi>10.1046/j.1365-2125.2003.01907.x</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Administration, Oral Administration, Sublingual Biological and medical sciences cobalamin deficiency Cystamine - analogs & derivatives Cystamine - blood General and cellular metabolism. Vitamins Humans Medical sciences Middle Aged oral Pharmacokinetics Pharmacology. Drug treatments Schilling Test sublingual Treatment Outcome Vitamin B 12 - administration & dosage Vitamin B 12 Deficiency - blood Vitamin B 12 Deficiency - drug therapy |
| title | Replacement therapy for vitamin B12 deficiency: comparison between the sublingual and oral route |
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