7-Dehydrocholesterol enhances ultraviolet A-induced oxidative stress in keratinocytes: Roles of NADPH oxidase, mitochondria, and lipid rafts

Long wavelength solar UVA radiation stimulates formation of reactive oxygen species (ROS) and prostaglandin E 2 (PGE 2), which are involved in skin photosensitivity and tumor promotion. High levels of 7-dehydrocholesterol (7-DHC), the precursor to cholesterol, cause exaggerated photosensitivity to U...

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Veröffentlicht in:	Free radical biology & medicine 2006-12, Vol.41 (11), p.1704-1718
Hauptverfasser:	Valencia, Antonio, Rajadurai, Anpuchchelvi, Carle, A. Bjorn, Kochevar, Irene E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Calcium - metabolism Cell Membrane - drug effects Cell Membrane - metabolism Cells, Cultured Cholesterol - metabolism Dehydrocholesterols - pharmacology Dinoprostone - metabolism Fluorescent Antibody Technique Humans Keratinocytes Keratinocytes - cytology Keratinocytes - drug effects Keratinocytes - radiation effects Lipid rafts Lipids - chemistry Liposomes Membrane Microdomains Mitochondria - drug effects Mitochondria - metabolism Mitochondria - radiation effects NADPH oxidase NADPH Oxidases - antagonists & inhibitors NADPH Oxidases - genetics NADPH Oxidases - metabolism Oxidative Stress Phospholipids - metabolism Reactive oxygen species Reactive Oxygen Species - metabolism RNA, Small Interfering - pharmacology Smith-Lemli-Opitz syndrome Smith-Lemli-Opitz Syndrome - metabolism Smith-Lemli-Opitz Syndrome - pathology Ultraviolet radiation Ultraviolet Rays - adverse effects
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