The hypoxia-inducible factor alpha pathway couples angiogenesis to osteogenesis during skeletal development

Skeletal development and turnover occur in close spatial and temporal association with angiogenesis. Osteoblasts are ideally situated in bone to sense oxygen tension and respond to hypoxia by activating the hypoxia-inducible factor alpha (HIF alpha) pathway. Here we provide evidence that HIF alpha p...

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Veröffentlicht in:	The Journal of clinical investigation 2007-06, Vol.117 (6), p.1616-1626
Hauptverfasser:	Wang, Ying, Wan, Chao, Deng, Lianfu, Liu, Ximeng, Cao, Xuemei, Gilbert, Shawn R, Bouxsein, Mary L, Faugere, Marie-Claude, Guldberg, Robert E, Gerstenfeld, Louis C, Haase, Volker H, Johnson, Randall S, Schipani, Ernestina, Clemens, Thomas L
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Basic Helix-Loop-Helix Transcription Factors - genetics Basic Helix-Loop-Helix Transcription Factors - physiology Bone Development - physiology Bones Cells, Cultured Gene Expression Growth Hypoxia-Inducible Factor 1, alpha Subunit - antagonists & inhibitors Hypoxia-Inducible Factor 1, alpha Subunit - genetics Hypoxia-Inducible Factor 1, alpha Subunit - physiology Mice Mice, Knockout Models, Biological Neovascularization Neovascularization, Physiologic Osteoblasts - physiology Osteogenesis - physiology Signal Transduction Vascular Endothelial Growth Factor A - physiology Von Hippel-Lindau Tumor Suppressor Protein - genetics
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