Depletion of RT6.1+ T lymphocytes alone is insufficient to induce diabetes in diabetes-resistant BB/Wor rats

Diabetes-prone (DP) BB/Wor rats are lymphopenic, lack RT6.1+ T cells, and spontaneously develop diabetes mellitus. Diabetes-resistant (DR) rats are not lymphopenic, have normal numbers of RT6.1+ T cells, and rarely become diabetic. It has been reported that RT6.1+ T-cell depletion induced insulitis...

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Veröffentlicht in:	The American journal of pathology 1990-03, Vol.136 (3), p.565-574
1. Verfasser:	Like, AA
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal - administration & dosage Antibodies, Monoclonal - immunology Biological and medical sciences Diabetes Mellitus, Experimental - epidemiology Diabetes Mellitus, Experimental - etiology Diabetes Mellitus, Experimental - pathology Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Histocompatibility Antigens - immunology Injections, Intraperitoneal Islets of Langerhans - immunology Islets of Langerhans - pathology Lymphocyte Depletion Medical sciences Pancreas - pathology Rats Rats, Inbred Strains T-Lymphocytes - immunology
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