Treatment with a novel hemigramicidin-TEMPO conjugate prolongs survival in a rat model of lethal hemorrhagic shock

We sought to develop a therapeutic agent that would permit prolongation of survival in rats subjected to lethal hemorrhagic shock (HS), even in the absence of resuscitation with asanguinous fluids or blood. We synthesized a series of compounds that consist of the electron scavenger and superoxide di...

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Veröffentlicht in:	Annals of surgery 2007-02, Vol.245 (2), p.305-314
Hauptverfasser:	MACIAS, Carlos A, CHIAO, Jeffrey W, JINGBO XIAO, ARORA, Devinder S, TYURINA, Yulia Y, DELUDE, Russell L, WIPF, Peter, KAGAN, Valerian E, FINK, Mitchell P
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Bacterial Agents - therapeutic use Biological and medical sciences Cells, Cultured Cyclic N-Oxides - therapeutic use Disease Models, Animal Drug Therapy, Combination Follow-Up Studies General aspects Gramicidin - therapeutic use Intestinal Mucosa - metabolism Intestinal Mucosa - pathology Lipid Peroxidation - drug effects Male Medical sciences Mitochondria - drug effects Mitochondria - metabolism Original Permeability - drug effects Rats Rats, Sprague-Dawley Shock, Hemorrhagic - drug therapy Shock, Hemorrhagic - metabolism Shock, Hemorrhagic - mortality Spin Labels Superoxide Dismutase - metabolism Survival Rate Treatment Outcome
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