Cytokeratin 8 Protects from Hepatotoxicity, and Its Ratio to Cytokeratin 18 Determines the Ability of Hepatocytes to Form Mallory Bodies

In alcoholic hepatitis, a severe form of alcohol-induced toxic liver injury, as well as in experimental intoxication of mice with the porphyrinogenic drugs griseofulvin and 3,5-diethoxycarbonyl-1,4-dihydrocollidine, hepatocytes form cytoplasmic protein aggregates (Mallory bodies; MBs. containing cyt...

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Veröffentlicht in:	The American journal of pathology 2000-04, Vol.156 (4), p.1263-1274
Hauptverfasser:	Zatloukal, Kurt, Stumptner, Cornelia, Lehner, Manfred, Denk, Helmut, Baribault, Helene, Eshkind, Leonid G., Franke, Werner W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bile Ducts - physiology Biological and medical sciences Chemical and Drug Induced Liver Injury Cytoplasm - physiology Cytoplasm - ultrastructure Cytoskeleton - ultrastructure Dicarbethoxydihydrocollidine Epithelium - physiology Gastroenterology. Liver. Pancreas. Abdomen Keratin-7 Keratins - genetics Keratins - metabolism Keratins - physiology Liver - cytology Liver - pathology Liver - physiology Liver Diseases - pathology Liver Diseases - prevention & control Liver. Biliary tract. Portal circulation. Exocrine pancreas Medical sciences Mice Mice, Inbred Strains Mice, Knockout - genetics Other diseases. Semiology Regular
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