Telomeric localization of the modified DNA base J in the genome of the protozoan parasite Leishmania

Base J or β-D-glucosylhydroxymethyluracil is a DNA modification replacing a fraction of thymine in the nuclear DNA of kinetoplastid parasites and of Euglena. J is located in the telomeric sequences of Trypanosoma brucei and in other simple repeat DNA sequences. In addition, J was found in the inacti...

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Veröffentlicht in:	Nucleic acids research 2007-04, Vol.35 (7), p.2116-2124
Hauptverfasser:	Genest, Paul-André, ter Riet, Bas, Cijsouw, Tony, van Luenen, Henri G.A.M, Borst, Piet
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Chromatography, Agarose Crithidia fasciculata Crithidia fasciculata - genetics DNA, Protozoan - chemistry Euglena Genome, Protozoan Glucosides - analysis Immunoblotting Immunoprecipitation Leishmania - genetics Leishmania major Molecular Biology Repetitive Sequences, Nucleic Acid Sequence Analysis, DNA Telomere - chemistry Trypanoplasma borreli Trypanosoma brucei Trypanosoma cruzi - genetics Trypanosoma equiperdum Uracil - analogs & derivatives Uracil - analysis
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