Dynamic binding of Ku80, Ku70 and NF90 to the IL-2 promoter in vivo in activated T-cells

IL-2 gene expression in activated T-cells is initiated by chromatin remodeling at the IL-2 proximal promoter and conversion of a transcriptional repressor into a potent transcriptional activator. A purine-box regulator complex was purified from activated Jurkat T-cell nuclei based on sequence-specif...

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Veröffentlicht in:	Nucleic acids research 2007-04, Vol.35 (7), p.2302-2310
Hauptverfasser:	Shi, Lingfang, Qiu, Daoming, Zhao, Guohua, Corthesy, Blaise, Lees-Miller, Susan, Reeves, Westley H, Kao, Peter N
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, Nuclear - metabolism Binding Sites Cells, Cultured Chromatin Immunoprecipitation Cyclosporine - pharmacology Diterpenes - pharmacology DNA-Activated Protein Kinase - metabolism DNA-Binding Proteins - metabolism Epoxy Compounds - pharmacology Humans Immunosuppressive Agents - pharmacology Interleukin-2 - genetics Jurkat Cells Ku Autoantigen Lymphocyte Activation Mice Mice, Inbred C57BL Molecular Biology Nuclear Factor 45 Protein - metabolism Nuclear Factor 90 Proteins - metabolism Phenanthrenes - pharmacology Promoter Regions, Genetic Protein Subunits - metabolism Response Elements T-Lymphocytes - immunology
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