A requirement for replication in activation of the ATR-dependent DNA damage checkpoint

Using the Xenopus egg extract system, we investigated the involvement of DNA replication in activation of the DNA damage checkpoint. We show here that DNA damage slows replication in a checkpoint-independent manner and is accompanied by replication-dependent recruitment of ATR and Rad1 to chromatin....

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Veröffentlicht in:	Genes & development 2002-09, Vol.16 (18), p.2327-2332
Hauptverfasser:	Lupardus, Patrick J, Byun, Tony, Yee, Muh-Ching, Hekmat-Nejad, Mohammad, Cimprich, Karlene A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Ataxia Telangiectasia Mutated Proteins Cell Cycle Cell Cycle Proteins - metabolism Checkpoint Kinase 1 DNA Damage DNA Replication - radiation effects DNA-Binding Proteins Endonucleases - genetics Endonucleases - metabolism Female In Vitro Techniques Methyl Methanesulfonate - toxicity Models, Biological Oocytes - drug effects Oocytes - metabolism Oocytes - radiation effects Protein Kinases - metabolism Protein-Serine-Threonine Kinases Recombinant Proteins - genetics Recombinant Proteins - metabolism Research Communication Ultraviolet Rays - adverse effects Xenopus Xenopus Proteins
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