The suppression of brain cold-stable microtubules in mice induces synaptic defects associated with neuroleptic-sensitive behavioral disorders

Neurons contain abundant subsets of highly stable microtubules that resist depolymerizing conditions such as exposure to the cold. Stable microtubules are thought to be essential for neuronal development, maintenance, and function. Previous work has indicated an important role of the microtubule-ass...

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Veröffentlicht in:	Genes & development 2002-09, Vol.16 (18), p.2350-2364
Hauptverfasser:	Andrieux, Annie, Salin, Paul A, Vernet, Muriel, Kujala, Pekka, Baratier, Julie, Gory-Fauré, Sylvie, Bosc, Christophe, Pointu, Hervé, Proietto, Dominique, Schweitzer, Annie, Denarier, Eric, Klumperman, Judith, Job, Didier
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Anxiety Agents - pharmacology Antipsychotic Agents - pharmacology Behavior, Animal - drug effects Behavior, Animal - physiology Brain - pathology Brain - physiopathology Cold Temperature Disease Models, Animal Female Humans Male Mice Mice, Knockout Microscopy, Electron Microtubule-Associated Proteins - deficiency Microtubule-Associated Proteins - genetics Microtubule-Associated Proteins - physiology Microtubules - pathology Microtubules - physiology Neuronal Plasticity Research Paper Synapses - pathology Synapses - physiology Synaptic Transmission
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