Levormeloxifene: safety, pharmacodynamics and pharmacokinetics in healthy postmenopausal women following single and multiple doses of a new selective oestrogen receptor modulator

Aims The safety, pharmacodynamics and pharmacokinetics of levormeloxifene, a selective oestrogen receptor modulator (SERM), were investigated in postmenopausal women following single doses and multiple dosing once daily up to 56 days. Methods The two randomized, double‐blind, placebo controlled st...

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Veröffentlicht in:	British journal of clinical pharmacology 2002-03, Vol.53 (3), p.284-295
Hauptverfasser:	Skrumsager, Birte K., Kiehr, Benedicte, Pedersen, Poul Christian, Gerrits, Mireille, Watson, Norma, Bjarnason, Ketil
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Aged antiatherogenic properties Area Under Curve Biological and medical sciences bone metabolism Bones, joints and connective tissue. Antiinflammatory agents collagen I C‐terminal telopeptide Double-Blind Method Drug Administration Schedule Female General and cellular metabolism. Vitamins healthy postmenopausal women Humans levormeloxifene Medical sciences Middle Aged multiple dose trial Osteoporosis, Postmenopausal - prevention & control pharmacokinetics Pharmacokinetics/Pharmacodynamics Pharmacology. Drug treatments Postmenopause Pyrrolidines - administration & dosage Pyrrolidines - pharmacokinetics Pyrrolidines - pharmacology Receptors, Estrogen - agonists safety selective oestrogen receptor modulator single dose trial Treatment Outcome
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