Antitumor effects of specific telomerase inhibitor GRN163 in human glioblastoma xenografts

Telomerase is a ribonucleoprotein complex that elongates telomeric DNA and appears to play an important role in cellular immortalization of cancers. Because telomerase is expressed in the vast majority of malignant gliomas but not in normal brain tissues, it is a logical target for gliomaspecific th...

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Veröffentlicht in:	Neuro-oncology (Charlottesville, Va.) Va.), 2004-07, Vol.6 (3), p.218-226
Hauptverfasser:	Ozawa, Tomoko, Gryaznov, Sergei M, Hu, Lily J, Pongracz, Krisztina, Santos, Raquel A, Bollen, Andrew W, Lamborn, Kathleen R, Deen, Dennis F
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Basic and Translational Investigations Brain Neoplasms - enzymology Brain Neoplasms - prevention & control Enzyme Inhibitors - pharmacology Enzyme Inhibitors - therapeutic use Female Glioblastoma - drug therapy Glioblastoma - enzymology Humans Male Mice Mice, Inbred BALB C Mice, Nude Oligonucleotides - pharmacology Oligonucleotides - therapeutic use Rats Rats, Nude Telomerase - antagonists & inhibitors Telomerase - metabolism Xenograft Model Antitumor Assays - methods
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