Modulation of cell spreading and migration by pp125FAK phosphorylation

We provide evidence for both matrix-dependent and pp60v-src tyrosine kinase-dependent modulation of cell migration via tyrosine phosphorylation of pp125FAK, a focal adhesion kinase, thought to be involved in integrin-mediated signaling. Enhanced pp125FAK tyrosine phosphorylation and cell spreading w...

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Veröffentlicht in:	The American journal of pathology 1995-09, Vol.147 (3), p.601-608
Hauptverfasser:	Sankar, S, Mahooti-Brooks, N, Hu, G, Madri, JA
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 Cells Animals Aorta - cytology Aorta - metabolism Biological and medical sciences Cattle Cell Adhesion Molecules - metabolism Cell Line, Transformed Cell Movement Cell physiology Endothelium, Vascular - cytology Endothelium, Vascular - metabolism Extracellular Matrix - physiology Focal Adhesion Kinase 1 Focal Adhesion Protein-Tyrosine Kinases Fundamental and applied biological sciences. Psychology Mice Molecular and cellular biology Motility and taxis Mutation Oncogene Protein pp60(v-src) - genetics Oncogene Protein pp60(v-src) - physiology Phosphorylation Protein-Tyrosine Kinases - metabolism Tyrosine - metabolism
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