Distinctive Roles of Neutrophils and Monocytes in Anti-Thy-1 Nephritis

Anti-Thy-1.1 glomerulonephritis as an experimental model for mesangial proliferative glomerulonephritis was induced in Wistar rats by a single injection of monoclonal IgG2a–anti-Thy-1.1 antibody (ER4G). This transient model is complement-mediated and leads to mesangial-cell (MC) lysis followed by MC...

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Veröffentlicht in:	The American journal of pathology 2000, Vol.156 (1), p.303-310
Hauptverfasser:	Westerhuis, Ralf, van Straaten, Suzanne C., van Dixhoorn, Mieneke G.A., van Rooijen, Nico, Verhagen, Nicole A.M., Dijkstra, Christine D., de Heer, Emile, Daha, Mohamed R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal - pharmacology Biological and medical sciences Cell Count - drug effects Clodronic Acid - pharmacology Female Glomerulonephritis Hematuria - etiology Isoantibodies - immunology Kidney Glomerulus - pathology Macrophage-1 Antigen - immunology Macrophages - pathology Medical sciences Monocytes - pathology Monocytes - physiology Nephritis - immunology Nephritis - pathology Nephritis - physiopathology Nephritis - urine Nephrology. Urinary tract diseases Nephropathies. Renovascular diseases. Renal failure Neutrophils - physiology Rats Rats, Wistar Regular
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