Characterization of a novel ectodermal signaling center regulating Tbx2 and Shh in the vertebrate limb

Normal patterning of the developing limb requires a tight restriction of Sonic hedgehog ( Shh) mRNA to the posterior margin of the limb bud. While several positive and negative regulatory factors have been identified which serve to position the Shh expression domain in the distal posterior limb, the...

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