Differential effects of five 'classical' scorpion β-toxins on rNav1.2a and DmNav1 provide clues on species-selectivity

In general, scorpion beta-toxins have been well examined. However, few in-depth studies have been devoted to species selectivity and affinity comparisons on the different voltage-activated Na(+) channels since they have become available as cloned channels that can be studied in heterologous expressi...

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Veröffentlicht in:	Toxicology and applied pharmacology 2007-01, Vol.218 (1), p.45-51
Hauptverfasser:	BOSMANS, Frank, MARTIN-EAUCLAIRE, Mane-France, TYTGAT, Jan
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Binding, Competitive Biochemistry Biochemistry, Molecular Biology Biological and medical sciences Brain - drug effects Brain - metabolism Female Insect Proteins - drug effects Insect Proteins - metabolism Life Sciences Medical sciences Membrane Potentials - drug effects Microinjections Molecular Sequence Data NAV1.2 Voltage-Gated Sodium Channel Nerve Tissue Proteins - drug effects Nerve Tissue Proteins - metabolism Neurotoxins - classification Neurotoxins - pharmacology Oocytes - metabolism Patch-Clamp Techniques Rats Scorpion Venoms - classification Scorpion Venoms - pharmacology Sodium Channels - drug effects Sodium Channels - metabolism Species Specificity Synaptosomes - drug effects Synaptosomes - metabolism Terminology as Topic Toxicology Xenopus laevis
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