Respiratory Reovirus 1/L Induction of Intraluminal Fibrosis, a Model of Bronchiolitis Obliterans Organizing Pneumonia, Is Dependent on T Lymphocytes

Bronchiolitis obliterans organizing pneumonia (BOOP) is a clinical syndrome characterized by perivascular/peribronchiolar leukocyte infiltration leading to the development of intraalveolar fibrosis. We have developed an animal model of BOOP where CBA/J mice infected with 1 × 10 6 plaque-forming unit...

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Veröffentlicht in:	The American journal of pathology 2003-10, Vol.163 (4), p.1467-1479
Hauptverfasser:	Majeski, Elizabeth I., Paintlia, Manjeet K., Lopez, Andrea D., Harley, Russell A., London, Steven D., London, Lucille
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Bronchoalveolar Lavage Fluid - cytology CD4-Positive T-Lymphocytes - pathology CD8-Positive T-Lymphocytes - pathology Chemokines - metabolism Cryptogenic Organizing Pneumonia - pathology Cryptogenic Organizing Pneumonia - physiopathology Cytokines - metabolism Disease Models, Animal Female Fibrosis Glucocorticoids - pharmacology Humans Inflammation - pathology Leukapheresis Lung - drug effects Lung - metabolism Lung - pathology Medical sciences Methylprednisolone - pharmacology Mice Mice, Inbred CBA Nasal Cavity - virology Orthoreovirus, Mammalian Pneumology Pulmonary Fibrosis - pathology Pulmonary Fibrosis - physiopathology Pulmonary Fibrosis - virology Regular Reoviridae Infections - complications Respiratory system : syndromes and miscellaneous diseases T-Lymphocytes
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