Ikaros Isoforms in Human Pituitary Tumors: Distinct Localization, Histone Acetylation, and Activation of the 5' Fibroblast Growth Factor Receptor-4 Promoter

Targeted expression of a human pituitary tumor derived-fibroblast growth factor receptor-4 (FGFR4) recapitulates pituitary tumorigenesis. We have shown that FGFR4 is a target for Ikaros, a zinc finger-containing transcription factor that localizes to heterochromatin regions and participates in highe...

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Veröffentlicht in:	The American journal of pathology 2003-09, Vol.163 (3), p.1177-1184
Hauptverfasser:	Ezzat, Shereen, Yu, Shunjiang, Asa, Sylvia L
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Adenoma - metabolism Adenoma - pathology Alternative Splicing Biological and medical sciences DNA-Binding Proteins Electrophoresis Endocrinopathies Histones - metabolism Humans Hypothalamus. Hypophysis. Epiphysis (diseases) Ikaros Transcription Factor Medical sciences Non tumoral diseases. Target tissue resistance. Benign neoplasms Pituitary Neoplasms - metabolism Pituitary Neoplasms - pathology Promoter Regions, Genetic Protein Isoforms - genetics Protein Isoforms - metabolism Receptor, Fibroblast Growth Factor, Type 4 Receptors, Fibroblast Growth Factor - genetics Receptors, Fibroblast Growth Factor - metabolism Regular RNA, Messenger - metabolism Tissue Distribution Transcription Factors - genetics Transcription Factors - metabolism
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