Analytical Validation of Telomerase Activity for Cancer Early Detection: TRAP/PCR-CE and hTERT mRNA Quantification Assay for High-Throughput Screening of Tumor Cells

Activation of telomerase plays a critical role in unlimited proliferation and immortalization of cells. Telomerase activity has been shown to correlate with tumor progression, indicating that tumors expressing this enzyme possess aggressive clinical behavior and that telomerase activity may be a use...

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Veröffentlicht in:	The Journal of molecular diagnostics : JMD 2004-08, Vol.6 (3), p.157-165
Hauptverfasser:	Jakupciak, John P, Wang, Wendy, Barker, Peter E, Srivastava, Sudhir, Atha, Donald H
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomarkers - analysis Cell Line, Tumor DNA-Binding Proteins Electrophoresis, Capillary - instrumentation Humans Neoplasms - diagnosis Polymerase Chain Reaction - instrumentation Regular RNA, Messenger - analysis RNA, Messenger - biosynthesis Robotics - instrumentation Robotics - methods Telomerase - genetics Telomerase - metabolism
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