CAP37, a Novel Inflammatory Mediator : Its Expression in Endothelial Cells and Localization to Atherosclerotic Lesions
Cationic antimicrobial protein of 37 kd (CAP37), originally isolated from human neutrophils, is an important multifunctional inflammatory mediator. Here we describe its localization within the vascular endothelium associated with atherosclerotic plaques. Evidence from in vitro immunocytochemical, No...
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| Veröffentlicht in: | The American journal of pathology 2002-03, Vol.160 (3), p.841-848 |
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| creator | Lee, Taunia D Gonzalez, Melva L Kumar, Padmasini Chary-Reddy, Saritha Grammas, Paula Pereira, H. Anne |
| description | Cationic antimicrobial protein of 37 kd (CAP37), originally isolated from human neutrophils, is an important multifunctional inflammatory mediator. Here we describe its localization within the vascular endothelium associated with atherosclerotic plaques. Evidence from in vitro immunocytochemical, Northern blot, and reverse transcriptase-polymerase chain reaction analysis indicates that CAP37 is induced in endothelial cells in response to inflammatory mediators. Endothelial-derived CAP37 shows sequence identity with an extensive region of neutrophil-derived CAP37. This is the first demonstration of endogenous endothelial CAP37, confirmed by sequence analysis. We suggest that, because of its induction and location in the endothelium and its known monocyte- and endothelial-activating capabilities, CAP37 has potential to modulate monocyte/endothelial dynamics at the vessel wall in inflammation. |
| doi_str_mv | 10.1016/S0002-9440(10)64907-3 |
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Anne</creator><creatorcontrib>Lee, Taunia D ; Gonzalez, Melva L ; Kumar, Padmasini ; Chary-Reddy, Saritha ; Grammas, Paula ; Pereira, H. Anne</creatorcontrib><description>Cationic antimicrobial protein of 37 kd (CAP37), originally isolated from human neutrophils, is an important multifunctional inflammatory mediator. Here we describe its localization within the vascular endothelium associated with atherosclerotic plaques. Evidence from in vitro immunocytochemical, Northern blot, and reverse transcriptase-polymerase chain reaction analysis indicates that CAP37 is induced in endothelial cells in response to inflammatory mediators. Endothelial-derived CAP37 shows sequence identity with an extensive region of neutrophil-derived CAP37. This is the first demonstration of endogenous endothelial CAP37, confirmed by sequence analysis. We suggest that, because of its induction and location in the endothelium and its known monocyte- and endothelial-activating capabilities, CAP37 has potential to modulate monocyte/endothelial dynamics at the vessel wall in inflammation.</description><identifier>ISSN: 0002-9440</identifier><identifier>EISSN: 1525-2191</identifier><identifier>DOI: 10.1016/S0002-9440(10)64907-3</identifier><identifier>PMID: 11891183</identifier><identifier>CODEN: AJPAA4</identifier><language>eng</language><publisher>Bethesda, MD: ASIP</publisher><subject>Animals ; Antimicrobial Cationic Peptides ; Arteriosclerosis - immunology ; Arteriosclerosis - metabolism ; Atherosclerosis (general aspects, experimental research) ; Biological and medical sciences ; Blood and lymphatic vessels ; Blood Proteins - biosynthesis ; Blood Proteins - genetics ; Blood Proteins - immunology ; Cardiology. Vascular system ; Carrier Proteins - biosynthesis ; Carrier Proteins - genetics ; Carrier Proteins - immunology ; Endothelium, Vascular - immunology ; Endothelium, Vascular - metabolism ; Flow Cytometry ; Gene Expression Regulation - immunology ; Humans ; Immunohistochemistry ; Inflammation Mediators - immunology ; Inflammation Mediators - metabolism ; Medical sciences ; Polymerase Chain Reaction ; Rats ; Regular</subject><ispartof>The American journal of pathology, 2002-03, Vol.160 (3), p.841-848</ispartof><rights>2002 INIST-CNRS</rights><rights>Copyright American Society for Investigative Pathology Mar 2002</rights><rights>Copyright © 2002, American Society for Investigative Pathology</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1867172/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1867172/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,315,728,781,785,886,27929,27930,53796,53798</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13554428$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11891183$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lee, Taunia D</creatorcontrib><creatorcontrib>Gonzalez, Melva L</creatorcontrib><creatorcontrib>Kumar, Padmasini</creatorcontrib><creatorcontrib>Chary-Reddy, Saritha</creatorcontrib><creatorcontrib>Grammas, Paula</creatorcontrib><creatorcontrib>Pereira, H. Anne</creatorcontrib><title>CAP37, a Novel Inflammatory Mediator : Its Expression in Endothelial Cells and Localization to Atherosclerotic Lesions</title><title>The American journal of pathology</title><addtitle>Am J Pathol</addtitle><description>Cationic antimicrobial protein of 37 kd (CAP37), originally isolated from human neutrophils, is an important multifunctional inflammatory mediator. Here we describe its localization within the vascular endothelium associated with atherosclerotic plaques. Evidence from in vitro immunocytochemical, Northern blot, and reverse transcriptase-polymerase chain reaction analysis indicates that CAP37 is induced in endothelial cells in response to inflammatory mediators. Endothelial-derived CAP37 shows sequence identity with an extensive region of neutrophil-derived CAP37. This is the first demonstration of endogenous endothelial CAP37, confirmed by sequence analysis. We suggest that, because of its induction and location in the endothelium and its known monocyte- and endothelial-activating capabilities, CAP37 has potential to modulate monocyte/endothelial dynamics at the vessel wall in inflammation.</description><subject>Animals</subject><subject>Antimicrobial Cationic Peptides</subject><subject>Arteriosclerosis - immunology</subject><subject>Arteriosclerosis - metabolism</subject><subject>Atherosclerosis (general aspects, experimental research)</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Blood Proteins - biosynthesis</subject><subject>Blood Proteins - genetics</subject><subject>Blood Proteins - immunology</subject><subject>Cardiology. Vascular system</subject><subject>Carrier Proteins - biosynthesis</subject><subject>Carrier Proteins - genetics</subject><subject>Carrier Proteins - immunology</subject><subject>Endothelium, Vascular - immunology</subject><subject>Endothelium, Vascular - metabolism</subject><subject>Flow Cytometry</subject><subject>Gene Expression Regulation - immunology</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Inflammation Mediators - immunology</subject><subject>Inflammation Mediators - metabolism</subject><subject>Medical sciences</subject><subject>Polymerase Chain Reaction</subject><subject>Rats</subject><subject>Regular</subject><issn>0002-9440</issn><issn>1525-2191</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNpdkV2LEzEUhoMobl39CUoQFAVHcyZfM14IpVQt1A9Qr0Mmk9mmZJJuMq2uv94U6656kZyE8-TlPW8QegjkJRAQr74QQuqqZYw8A_JcsJbIit5CM-A1r2po4TaaXSNn6F7O23IVtCF30RlA05ZFZ-iwmH-m8gXW-GM8WI9XYfB6HPUU0xX-YHt3POHXeDVlvPyxSzZnFwN2AS9DH6eN9U57vLDeZ6xDj9fRaO9-6ulITRHPC5JiNr7skzN4bY_v8310Z9A-2weneo6-vV1-Xbyv1p_erRbzdbWhnEyVNtBRDdIezbZmsCB42zM5WNYxQUg3MOhsV3dcWG4k7UXXc9ITwqQRTAz0HL35rbvbd6PtjQ1T0l7tkht1ulJRO_VvJ7iNuogHBY2QIOsi8PQkkOLl3uZJjS6bMq4ONu6zkiXvBogs4OP_wG3cp1CGU3VJW7Q1bwr06G871z7-_EcBnpwAnUuQQ9LBuHzDUc4Zq5sbWxt3sfnuklV51N4XWVB6uwNBFFUNA_oL_Suovw</recordid><startdate>20020301</startdate><enddate>20020301</enddate><creator>Lee, Taunia D</creator><creator>Gonzalez, Melva L</creator><creator>Kumar, Padmasini</creator><creator>Chary-Reddy, Saritha</creator><creator>Grammas, Paula</creator><creator>Pereira, H. 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Anne</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h350t-ac1b3a17e11839cfe1659d47fe4b4600bf41beb2b56e5c73d6bd50d0047c646f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Animals</topic><topic>Antimicrobial Cationic Peptides</topic><topic>Arteriosclerosis - immunology</topic><topic>Arteriosclerosis - metabolism</topic><topic>Atherosclerosis (general aspects, experimental research)</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>Blood Proteins - biosynthesis</topic><topic>Blood Proteins - genetics</topic><topic>Blood Proteins - immunology</topic><topic>Cardiology. Vascular system</topic><topic>Carrier Proteins - biosynthesis</topic><topic>Carrier Proteins - genetics</topic><topic>Carrier Proteins - immunology</topic><topic>Endothelium, Vascular - immunology</topic><topic>Endothelium, Vascular - metabolism</topic><topic>Flow Cytometry</topic><topic>Gene Expression Regulation - immunology</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Inflammation Mediators - immunology</topic><topic>Inflammation Mediators - metabolism</topic><topic>Medical sciences</topic><topic>Polymerase Chain Reaction</topic><topic>Rats</topic><topic>Regular</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lee, Taunia D</creatorcontrib><creatorcontrib>Gonzalez, Melva L</creatorcontrib><creatorcontrib>Kumar, Padmasini</creatorcontrib><creatorcontrib>Chary-Reddy, Saritha</creatorcontrib><creatorcontrib>Grammas, Paula</creatorcontrib><creatorcontrib>Pereira, H. 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Anne</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>CAP37, a Novel Inflammatory Mediator : Its Expression in Endothelial Cells and Localization to Atherosclerotic Lesions</atitle><jtitle>The American journal of pathology</jtitle><addtitle>Am J Pathol</addtitle><date>2002-03-01</date><risdate>2002</risdate><volume>160</volume><issue>3</issue><spage>841</spage><epage>848</epage><pages>841-848</pages><issn>0002-9440</issn><eissn>1525-2191</eissn><coden>AJPAA4</coden><abstract>Cationic antimicrobial protein of 37 kd (CAP37), originally isolated from human neutrophils, is an important multifunctional inflammatory mediator. Here we describe its localization within the vascular endothelium associated with atherosclerotic plaques. Evidence from in vitro immunocytochemical, Northern blot, and reverse transcriptase-polymerase chain reaction analysis indicates that CAP37 is induced in endothelial cells in response to inflammatory mediators. Endothelial-derived CAP37 shows sequence identity with an extensive region of neutrophil-derived CAP37. This is the first demonstration of endogenous endothelial CAP37, confirmed by sequence analysis. We suggest that, because of its induction and location in the endothelium and its known monocyte- and endothelial-activating capabilities, CAP37 has potential to modulate monocyte/endothelial dynamics at the vessel wall in inflammation.</abstract><cop>Bethesda, MD</cop><pub>ASIP</pub><pmid>11891183</pmid><doi>10.1016/S0002-9440(10)64907-3</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Antimicrobial Cationic Peptides Arteriosclerosis - immunology Arteriosclerosis - metabolism Atherosclerosis (general aspects, experimental research) Biological and medical sciences Blood and lymphatic vessels Blood Proteins - biosynthesis Blood Proteins - genetics Blood Proteins - immunology Cardiology. Vascular system Carrier Proteins - biosynthesis Carrier Proteins - genetics Carrier Proteins - immunology Endothelium, Vascular - immunology Endothelium, Vascular - metabolism Flow Cytometry Gene Expression Regulation - immunology Humans Immunohistochemistry Inflammation Mediators - immunology Inflammation Mediators - metabolism Medical sciences Polymerase Chain Reaction Rats Regular |
| title | CAP37, a Novel Inflammatory Mediator : Its Expression in Endothelial Cells and Localization to Atherosclerotic Lesions |
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