Genomic Imbalances Associated with Acquired Resistance to Platinum Analogues

During the past several years, a panel of human tumor cell lines (predominantly ovarian) with acquired resistance to cisplatin, the orally bioavailable analogue JM216, and the structurally hindered analogue AMD473, has been established and characterized for underlying mechanisms of resistance. We ha...

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Veröffentlicht in:	The American journal of pathology 1999-07, Vol.155 (1), p.77-84
Hauptverfasser:	Leyland-Jones, Brian, Kelland, Lloyd R., Harrap, Kenneth R., Hiorns, Lynne R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Antineoplastic Agents - pharmacology Biological and medical sciences Chemotherapy Chromosome Aberrations - genetics Chromosomes - genetics Cisplatin - pharmacology Drug Resistance, Neoplasm - genetics Genome Humans Medical sciences Nucleic Acid Hybridization Organoplatinum Compounds - pharmacology Pharmacology. Drug treatments Platinum - pharmacology Short Communication Tumor Cells, Cultured
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