Germline and Somatic Mutations of the STK11/LKB1 Peutz-Jeghers Gene in Pancreatic and Biliary Cancers

Peutz-Jeghers syndrome (PJS) is an autosomal-dominant disorder characterized by hamartomatous polyps in the gastrointestinal tract and by pigmented macules of the lips, buccal mucosa, and digits. Less appreciated is the fact that PJS also predisposes patients to an increased risk of gastrointestinal...

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Veröffentlicht in:	The American journal of pathology 1999-06, Vol.154 (6), p.1835-1840
Hauptverfasser:	Su, Gloria H., Hruban, Ralph H., Bansal, Ravi K., Bova, G. Steven, Tang, David J., Shekher, Manu C., Westerman, Anne Marie, Entius, Mark M., Goggins, Michael, Yeo, Charles J., Kern, Scott E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - complications Adenocarcinoma - genetics Adult Biological and medical sciences Blotting, Southern Cell Line Common Bile Duct Neoplasms - genetics DNA Mutational Analysis Female Gastroenterology. Liver. Pancreas. Abdomen Genetic Markers Germ-Line Mutation Humans Liver. Biliary tract. Portal circulation. Exocrine pancreas Loss of Heterozygosity Medical sciences Mutation Pancreatic Neoplasms - complications Pancreatic Neoplasms - genetics Peutz-Jeghers Syndrome - complications Peutz-Jeghers Syndrome - genetics Polymerase Chain Reaction Protein-Serine-Threonine Kinases - genetics Regular Sequence Deletion Tumors
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