Decreased Proliferation and Altered Differentiation in Osteoblasts from Genetically and Clinically Distinct Craniosynostotic Disorders

Craniosynostoses are a heterogeneous group of disorders characterized by premature fusion of cranial sutures. Mutations in fibroblast growth factor receptors (FGFRs) have been associated with a number of such conditions. Nevertheless, the cellular mechanism(s) involved remain unknown. We analyzed ce...

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Veröffentlicht in:	The American journal of pathology 1999-05, Vol.154 (5), p.1465-1477
Hauptverfasser:	Fragale, Alessandra, Tartaglia, Marco, Bernardini, Silvia, Di Stasi, A.M. Michela, Di Rocco, Concezio, Velardi, Francesco, Teti, Anna, Battaglia, Piero A., Migliaccio, Silvia
Format:	Artikel
Sprache:	eng
Schlagworte:	Acrocephalosyndactylia - genetics Acrocephalosyndactylia - pathology Alkaline Phosphatase - analysis Biological and medical sciences Cell Differentiation - physiology Cell Division - physiology Cells, Cultured Craniosynostoses - genetics Craniosynostoses - pathology Diseases of the osteoarticular system Humans Infant Isoenzymes - analysis Male Malformations and congenital and or hereditary diseases involving bones. Joint deformations Medical sciences Mutation Osteoblasts - pathology Phenotype Protein Kinase C - analysis Receptors, Fibroblast Growth Factor - genetics Regular Staining and Labeling
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