Some implications of receptor theory for in vivo assessment of agonists, antagonists and inverse agonists

Drug effects can be classified into three major phenotypes: agonist, antagonist and inverse agonist. Agonist and inverse agonist effects are associated with receptor activation and inactivation, respectively, whereas antagonism implies that a drug produces no effect when administered alone but block...

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Veröffentlicht in:	Biochemical pharmacology 2006-06, Vol.71 (12), p.1663-1670
1. Verfasser:	Negus, S. Stevens
Format:	Artikel
Sprache:	eng
Schlagworte:	Agonist Antagonist Biological and medical sciences Constitutive activity In vivo Inverse agonist Medical sciences Models, Theoretical Pharmacology. Drug treatments Receptor theory Receptors, Cell Surface - agonists Receptors, Cell Surface - antagonists & inhibitors
Online-Zugang:	Volltext
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