Autoantibodies against heat shock protein 60 mediate endothelial cytotoxicity

Stress or heat shock proteins (hsp) are a family of approximately two dozen proteins with a high degree of amino acid sequence homology between different species, ranging from prokaryotes to humans, and are representative of a generalized response to environmental and metabolic stressors. Our previo...

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Veröffentlicht in:	The Journal of clinical investigation 1995-12, Vol.96 (6), p.2569-2577
Hauptverfasser:	Schett, G, Xu, Q, Amberger, A, Van der Zee, R, Recheis, H, Willeit, J, Wick, G
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Animals Antibody-Dependent Cell Cytotoxicity Arteriosclerosis - immunology Arteriosclerosis - metabolism Arteriosclerosis - pathology Autoantibodies - isolation & purification Autoantibodies - pharmacology Autoantibodies - physiology Blood Donors Carotid Artery Diseases - immunology Carotid Artery Diseases - metabolism Carotid Artery Diseases - pathology Cells, Cultured Chaperonin 60 - biosynthesis Chaperonin 60 - immunology Chromatography, Affinity Complement System Proteins - physiology Cytotoxicity, Immunologic - physiology Endothelium, Vascular - metabolism Endothelium, Vascular - pathology Female Fluorescent Antibody Technique, Indirect Gene Expression Heat-Shock Proteins - immunology Humans Immunoglobulin A - isolation & purification Immunoglobulin A - pharmacology Immunoglobulin A - physiology Immunoglobulin G - isolation & purification Immunoglobulin G - pharmacology Immunoglobulin G - physiology Kinetics Male Reference Values Umbilical Veins
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