Potent inhibitory effects of transplantable rat glucagonomas and insulinomas on the respective endogenous islet cells are associated with pancreatic apoptosis

Effects of transplantable rat insulinomas (IN) and glucagonomas (GLU) on the endogenous pancreas were analyzed using morphometry, immunocytochemistry, in situ hybridization, and staining for apoptotic cells. Hyperinsulinemia (IN-rats) and hyper-GLP-1/glucagonemia (GLU-rats) were both associated with...

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Veröffentlicht in:	The Journal of clinical investigation 1995-11, Vol.96 (5), p.2227-2235
Hauptverfasser:	Blume, N, Skouv, J, Larsson, L I, Holst, J J, Madsen, O D
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Base Sequence Cell Transplantation Gene Expression Regulation Glucagonoma - physiopathology Immunohistochemistry In Situ Hybridization Insulin - biosynthesis Insulin - genetics Insulinoma - physiopathology Islets of Langerhans - pathology Molecular Sequence Data Neoplasm Transplantation Pancreatic Neoplasms - physiopathology Proinsulin - biosynthesis Proinsulin - genetics Rats
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