Tissue inhibitor of metalloproteinases-3 is a component of Bruch's membrane of the eye

Mutations in tissue inhibitor of metalloproteinases (TIMP)-3 are found in some patients with Sorsby's fundus dystrophy, a retinal degeneration characterized by abnormal deposits in Bruch's membrane and choroidal neovascularization. The purpose of this study was to localize TIMP-3 in the re...

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Veröffentlicht in:	The American journal of pathology 1997-01, Vol.150 (1), p.323-328
Hauptverfasser:	Fariss, RN, Apte, SS, Olsen, BR, Iwata, K, Milam, AH
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Amino Acid Sequence Antibodies, Monoclonal - chemistry Biological and medical sciences Blotting, Western Bruch Membrane - enzymology Bruch Membrane - immunology Extracellular Matrix - enzymology Humans Medical sciences Molecular Sequence Data Ophthalmology Protease Inhibitors - analysis Protease Inhibitors - immunology Proteins - analysis Proteins - immunology Retinopathies Tissue Inhibitor of Metalloproteinase-3
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